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PZ0123

Sigma-Aldrich

Avridine

≥97% (HPLC)

Synonym(s):

CP 20961, N,N-Dioctadecyl-N′,N′-bis(2-hydroxyethyl)-1,3-diaminopropane, N,N-Dioctadecyl-N′,N′-bis(2-hydroxyethyl)propanediamine

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About This Item

Empirical Formula (Hill Notation):
C43H90N2O2
CAS Number:
35607-20-6
Molecular Weight:
667.19
MDL number:
MFCD00673242
UNSPSC Code:
51111800
PubChem Substance ID:
329823713
NACRES:
NA.77

Assay

≥97% (HPLC)

form

powder

color

white to off-white

solubility

DMSO: ≥5 mg/mL (with warming to 60 °C for 5 minutes)

storage temp.

room temp

SMILES string

CCCCCCCCCCCCCCCCCCN(CCCCCCCCCCCCCCCCCC)CCCN(CCO)CCO

InChI

1S/C43H90N2O2/c1-3-5-7-9-11-13-15-17-19-21-23-25-27-29-31-33-36-44(38-35-39-45(40-42-46)41-43-47)37-34-32-30-28-26-24-22-20-18-16-14-12-10-8-6-4-2/h46-47H,3-43H2,1-2H3

InChI key

WXNRAKRZUCLRBP-UHFFFAOYSA-N

Biochem/physiol Actions

Avridine is a potent synthetic adjuvant that can induce arthritis in most rat strains; immunomodulator and interferon-inducing.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Chenguang Zhou et al.
Therapeutic delivery, 3(6), 715-723 (2012-07-31)
Lack of safe and efficient delivery of siRNA remains the greatest hurdle for the therapeutic application of siRNA. This article reports synthesis and evaluation of novel lipoidal amine-based nanocarrier (LANC) formulations for siRNA delivery. Physicochemical properties were analyzed for LANC
Administration of intraliposomal CP20961 to mice activates peritoneal macrophages and augments serum antibody response to Toxoplasma gondii.
D Mack et al.
The Journal of eukaryotic microbiology, 41(5), 12S-12S (1994-09-01)
Comparative susceptibility of DA, LEW, and LEW.1AV1 rats to arthritis induced with different arthritogens: mineral oil, mycobacteria, muramyl dipeptide, avridine and rat collagen type II.
J C Lorentzen et al.
Transplantation proceedings, 29(3), 1692-1693 (1997-05-01)
Genetic factors regulating experimental arthritis in mice and rats.
R L Wilder et al.
Current directions in autoimmunity, 1, 121-165 (2002-01-17)
C Vingsbo et al.
Clinical and experimental immunology, 99(3), 359-363 (1995-03-01)
Avridine is a potent synthetic adjuvant that can induce arthritis is most rat strains. The clinical appearance and histopathology of avridine-induced arthritis show great similarity to other arthritis models such as collagen-induced arthritis. In LEW and DA rats the avridine-induced
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