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PZ0367

Sigma-Aldrich

PF-02413873

≥98% (HPLC)

Synonym(s):

4-[3-Cyclopropyl-1-(mesylmethyl)-5-methyl-1H-pyrazol-4-yl]oxy-2,6-dimethylbenzonitrile, 4-[[3-Cyclopropyl-5-methyl-1-[(methylsulfonyl)methyl]-1H-pyrazol-4-yl]oxy]-2,6-dimethyl-benzonitrile, PF 2413873, PF-2413873

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25 MG
₩149,104
100 MG
₩219,951
250 MG
₩384,787
1 G
₩1,078,844

₩149,104


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25 MG
₩149,104
100 MG
₩219,951
250 MG
₩384,787
1 G
₩1,078,844

About This Item

Empirical Formula (Hill Notation):
C18H21N3O3S
CAS Number:
Molecular Weight:
359.44
MDL number:
UNSPSC Code:
12352200
NACRES:
NA.77

₩149,104


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Quality Level

Assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

room temp

SMILES string

CC1=C(C#N)C(C)=CC(OC2=C(C)N(CS(=O)(C)=O)N=C2C3CC3)=C1

InChI

1S/C18H21N3O3S/c1-11-7-15(8-12(2)16(11)9-19)24-18-13(3)21(10-25(4,22)23)20-17(18)14-5-6-14/h7-8,14H,5-6,10H2,1-4H3

InChI key

QSFGZNVRVZHUGV-UHFFFAOYSA-N

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1 of 4

This Item
SAB4504275SAB4501974SAB4502282
conjugate

unconjugated

conjugate

unconjugated

conjugate

unconjugated

conjugate

unconjugated

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

biological source

rabbit

biological source

rabbit

biological source

rabbit

biological source

rabbit

UniProt accession no.

P06685

UniProt accession no.

P05023

UniProt accession no.

P05023

UniProt accession no.

P62136

mol wt

antigen 113 kDa

mol wt

antigen 113 kDa

mol wt

antigen 112 kDa

mol wt

antigen 37 kDa

Biochem/physiol Actions

PF-02413873 is a potent, selective and fully competitive non-steroidal progesterone receptor (PR) antagonist that blocks progesterone binding and PR nuclear translocation. PF-02413873 suppresses endometrial growth in the macaque and human.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


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    Peter J Bungay et al.
    Drug metabolism and disposition: the biological fate of chemicals, 39(8), 1396-1405 (2011-05-06)
    The recently discovered selective nonsteroidal progesterone receptor (PR) antagonist 4-[3-cyclopropyl-1-(methylsulfonylmethyl)-5-methyl-1H-pyrazol-4-yl]oxy-2,6-dimethylbenzonitrile (PF-02413873) was characterized in metabolism studies in vitro, in preclinical pharmacokinetics in rat and dog, and in an initial pharmacokinetic study in human volunteers. Clearance (CL) of PF-02413873 was found
    David C Howe et al.
    The Journal of pharmacology and experimental therapeutics, 339(2), 642-653 (2011-08-19)
    There is considerable ongoing investment in the research and development of selective progesterone receptor (PR) modulators for the treatment of gynecological conditions such as endometriosis. Here, we provide the first report on the clinical evaluation of a nonsteroidal progesterone receptor

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