S1885

Suberic acid bis(N-hydroxysuccinimide ester)

≥95%, powder

• Synonym(s): Disuccinimidyl suberate, Disuccinimidyl octanedioate, Disuccinimidyl suberate (DSS)
• Empirical Formula (Hill Notation): C₁₆H₂₀N₂O₈
• CAS Number: 68528-80-3
• Molecular Weight: 368.34
• MDL number: MFCD00049059
• UNSPSC Code: 12352100
• PubChem Substance ID: 24899500
• NACRES: NA.21

Properties

• Quality Level: 200
• Assay: ≥95%
• form: powder
• reaction suitability: reagent type: cross-linking reagent
• solubility: chloroform: 50 mg/mL; DMF: soluble; aqueous buffer: slightly soluble (may require 5-10% organic solvent in coupling mixture.)
• functional group: imide
• storage temp.: 2-8°C
• SMILES string: O=C(CCCCCCC(=O)ON1C(=O)CCC1=O)ON2C(=O)CCC2=O
• InChI: 1S/C16H20N2O8/c19-11-7-8-12(20)17(11)25-15(23)5-3-1-2-4-6-16(24)26-18-13(21)9-10-14(18)22/h1-10H2
• InChI key: ZWIBGKZDAWNIFC-UHFFFAOYSA-N

Description

General description

Suberic acid bis(N-hydroxysuccinimide ester) is a homobifunctional cross-linking reagent with amine reactivity. Typically coupled to molecules containing primary amine by amide bond buffered at pH 7.5 (6.5-8.5). Suberic acid bis(N-hydroxysuccinimide ester) incorporates an 8-atom linker.

Application

Suberic acid bis(N-hydroxysuccinimide ester) has been:

• supplemented in pierce lysis buffer used for immunoprecipitation
• used to conjugate the oligonucleotide standards to gelatin
• used in cross-linking of ASC (apoptosis-associated speck-like protein containing a caspase recruitment domain) oligomers

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves