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SMB00292

Sigma-Aldrich

Fengycin

≥90%

Synonym(s):

Fengycin, Plipastatin

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About This Item

Empirical Formula (Hill Notation):
C72H110N12O20
Molecular Weight:
1463.71
UNSPSC Code:
51102829
NACRES:
NA.85

biological source

Bacillus subtilis

Quality Level

Assay

≥90%

form

powder

color

, Off-White to Light Yellow to Light Brown

antibiotic activity spectrum

fungi

Mode of action

cell membrane | interferes

storage temp.

2-8°C

General description

Chemical structure: peptide
Fengycin is a lipopeptide complex which is synthesized by Bacillus subtilis strain F-29-3. It is an antifungal compound, and is made up of two components namely, fengycin A and fengycin B. Fengycin A contains 1 D-Ala, 1 L-Ile, 1 L-Pro, 1 D-allo-Thr, 3 L-Glx, 1 D-Tyr, 1 L-Tyr, 1 D-Orn, whereas fengycin B contains D-Val instead of D-Ala.

Application

Fengycin may be used for the sterilization of E. coli., and for the inactivation of spores of Bacillus cereus.

Biochem/physiol Actions

Fengycin shows antifungal properties against filamentous fungi, but has no action against yeast and bacteria. Certain unsaturated fatty acids facilitate the antifungal property, whereas sterols, phospholipids and oleic acid act as antagonists. It produces morphological abnormalities in fungi including curling, bulging and empyting of hyphae. Thus, it mainly functions through its effects on the plasma membrane.

Packaging

5MG

Storage and Stability

Store at 2 to 8 °C. (Keep container tightly closed in a dry and well-ventilated place. Light sensitive.)

Other Notes

Keep container tightly closed in a dry and well-ventilated place. Light sensitive.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


Certificates of Analysis (COA)

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Antifungal effects of bacilysin and fengymycin from Bacillus subtilis F-29-3 a comparsion with activities of other Bacillus antibiotics.
Loeffler W., et al
Journal of Phytopathology, 115, 204-213 (1986)
Marc Ongena et al.
Environmental microbiology, 9(4), 1084-1090 (2007-03-16)
Multiple strains of Bacillus spp. were demonstrated to stimulate plant defence responses. However, very little is known about the nature of molecular determinants secreted by these Gram-positive bacteria that are responsible for the elicitation of the induced systemic resistance (ISR)
N Vanittanakom et al.
The Journal of antibiotics, 39(7), 888-901 (1986-07-01)
Fengycin is an antifungal lipopeptide complex produced by Bacillus subtilis strain F-29-3. It inhibits filamentous fungi but is ineffective against yeast and bacteria. The inhibition is antagonized by sterols, phospholipids and oleic acid, whereas two other unsaturated fatty acids increase
Optimization of sterilization of Escherichia coli in milk by surfactin and fengycin using a response surface method.
Huang X
Current Microbiology, 56(4), 376-381 (2008)
Marc Ongena et al.
Trends in microbiology, 16(3), 115-125 (2008-02-22)
In the context of biocontrol of plant diseases, the three families of Bacillus lipopeptides - surfactins, iturins and fengycins were at first mostly studied for their antagonistic activity for a wide range of potential phytopathogens, including bacteria, fungi and oomycetes.

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