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USP

Glycine

United States Pharmacopeia (USP) Reference Standard

Synonym(s):

Aminoacetic acid, Aminoethanoic acid, Glycocoll

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About This Item

Linear Formula:
NH2CH2COOH
CAS Number:
56-40-6
Molecular Weight:
75.07
Beilstein:
635782
MDL number:
MFCD00008131
UNSPSC Code:
41116107
PubChem Substance ID:
329749956
NACRES:
NA.24

grade

pharmaceutical primary standard

API family

glycine

manufacturer/tradename

USP

pH

4(0.2 molar aqueous solution)

pKa (25 °C)

(1) 2.35, (2) 9.60
2.35

mp

240 °C (dec.) (lit.)

application(s)

pharmaceutical (small molecule)

format

neat

SMILES string

NCC(O)=O

InChI

1S/C2H5NO2/c3-1-2(4)5/h1,3H2,(H,4,5)

InChI key

DHMQDGOQFOQNFH-UHFFFAOYSA-N

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General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Glycine USP reference standard, intended for use in specified quality tests and assays as specified in the USP compendia. Also, for use with USP monographs such as:
  • Glycine Irrigation
  • Theophylline Sodium Glycinate
  • Glycyl-l-tyrosine
  • Glycyl-l-glutamine
  • Pyrroloquinoline Quinone Disodium

Biochem/physiol Actions

Inhibitory neurotransmitter in spinal cord, allosteric regulator of NMDA receptors.

Analysis Note

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

Other Notes

Sales restrictions may apply.

related product

Product No.
Description
Pricing

Storage Class Code

13 - Non Combustible Solids

WGK

WGK 1

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Theophylline Sodium Glycinate
United States Pharmacopeia and National Formulary
United States Pharmacopeia, 4333-4333 (2020)
Glycyl-l-tyrosine
United States Pharmacopeia and National Formulary
United States Pharmacopeia, 39(4), 5059-5059 (2020)
Glycine
United States Pharmacopeia and National Formulary
United States Pharmacopeia, 38(6), 6082-6082 (2018)
Alexander Carvajal-González et al.
Brain : a journal of neurology, 137(Pt 8), 2178-2192 (2014-06-22)
The clinical associations of glycine receptor antibodies have not yet been described fully. We identified prospectively 52 antibody-positive patients and collated their clinical features, investigations and immunotherapy responses. Serum glycine receptor antibody endpoint titres ranged from 1:20 to 1:60 000.
Pierre Chue
Current pharmaceutical design, 19(7), 1311-1320 (2012-12-01)
Primary negative symptoms (affective flattening or blunting, alogia, avolition) are prominent in approximately 20% of individuals suffering from schizophrenia. These symptoms are particularly associated with impaired functional outcome and poor prognosis. This is in part due to the lack of
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