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Merck
모든 사진(1)

문서

81300

Sigma-Aldrich

Poly(ethylene glycol)

average MN 20,000, hydroxyl

동의어(들):

Polyethylene glycol, PEG

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모든 사진(1)

About This Item

Linear Formula:
H(OCH2CH2)nOH
CAS Number:
25322-68-3
MDL number:
MFCD00081839
UNSPSC 코드:
12352104
PubChem Substance ID:
24887748
NACRES:
NA.23

product name

Poly(ethylene glycol), average Mn 20,000

형태

flakes

Quality Level

200

분자량

average Mn 20,000

mp

63-66 °C

Ω-끝

hydroxyl

α-끝

hydroxyl

SMILES string

C(CO)O

InChI

1S/C2H6O2/c3-1-2-4/h3-4H,1-2H2

InChI key

LYCAIKOWRPUZTN-UHFFFAOYSA-N

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관련 카테고리

일반 설명

Polyethylene glycol (PEG) is a hydrophilic polymer. It can be easily synthesized by the anionic ring opening polymerization of ethylene oxide, into a range molecular weights and variety of end groups. When crosslinked into networks PEG can have high water content, forming “hydrogels”. Hydrogel formation can be initiated by either crosslinking PEG by ionizing radiation or by covalent crosslinking of PEG macromers with reactive chain ends. PEG is a suitable material for biological applications because it does not trigger an immune response.

애플리케이션

PEG has been used to modify therapeutic proteins and peptides to increase their solubility and lower their toxicity.

Photopolymerized PEG hydrogels have emerging applications in the fabrication of bioactive and immunoisolating barriers for encapsulation of cells.

기타 정보

Molecular weight: Mn 16,000-24,000

Storage Class Code

11 - Combustible Solids

WGK

WGK 1

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

개인 보호 장비

Eyeshields, Gloves, type N95 (US)

시험 성적서(COA)

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문서 라이브러리 방문

Xu Zhang et al.
Langmuir : the ACS journal of surfaces and colloids, 28(40), 14330-14337 (2012-09-20)
Understanding the interface between DNA and nanomaterials is crucial for rational design and optimization of biosensors and drug delivery systems. For detection and delivery into cells, where high concentrations of cellular proteins are present, another layer of complexity is added.
Chien-Chi Lin et al.
Biomaterials, 32(36), 9685-9695 (2011-09-20)
Hydrogels provide three-dimensional frameworks with tissue-like elasticity and high permeability for culturing therapeutically relevant cells or tissues. While recent research efforts have created diverse macromer chemistry to form hydrogels, the mechanisms of hydrogel polymerization for in situ cell encapsulation remain
Carrie F Olson-Manning
Molecular biology and evolution, 37(8), 2257-2267 (2020-03-21)
Metabolic networks are complex cellular systems dependent on the interactions among, and regulation of, the enzymes in the network. Although there is great diversity of types of enzymes that make up metabolic networks, the models meant to understand the possible
Teagan E Bate et al.
Soft matter, 15(25), 5006-5016 (2019-06-06)
Self-organization of kinesin-driven, microtubule-based 3D active fluids relies on the collective dynamics of single microtubules. However, the connection between macroscopic fluid flows and microscopic motion of microtubules remains unclear. In this work, the motion of single microtubules was characterized by
Oliver J Harrison et al.
Cell reports, 30(8), 2655-2671 (2020-02-27)
Non-clustered δ1- and δ2-protocadherins, close relatives of clustered protocadherins, function in cell adhesion and motility and play essential roles in neural patterning. To understand the molecular interactions underlying these functions, we used solution biophysics to characterize binding of δ1- and
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문서

2D 및 3D 세포 배양을 위한 분해성 폴리(에틸렌 글리콜) 하이드로겔

조직 공학과 약물 전달과 같은 생명 공학의 진보는 다양한 기능성 바이오 소재에 대한 수요 증가를 동반합니다. 연구의 집중 관심 대상이 되어온 바이오 소재의 한 분야는 바로 하이드로겔으로, 화학적으로나 물리적으로 세포의 자연 환경과 유사하게 닮아 있기 때문에 세포를 키우는 토대로 사용될 수 있습니다. 본 기술 문서에서는 일반적으로 면역 반응을 유발하지 못하기 때문에 생물학적 용도로 적합한 PEG(폴리에틸렌 글리콜) 하이드로겔에 대해 상세하게 논의합니다. PEG는 쉽게 이용할 수 있으며, 손쉽게 고분자를 수정하여 세포 배양을 위한 2D 및 3D 뼈대를 포함한 하이드로겔 구성에 광범위하게 사용할 수 있습니다. 또한 분해성 결합을 통해 치료제 출시를 위한 다양한 응용분야에도 도움을 줍니다.

Degradable Poly(ethylene glycol) Hydrogels for 2D and 3D Cell Culture

Progress in biotechnology fields such as tissue engineering and drug delivery is accompanied by an increasing demand for diverse functional biomaterials. One class of biomaterials that has been the subject of intense research interest is hydrogels, because they closely mimic the natural environment of cells, both chemically and physically and therefore can be used as support to grow cells. This article specifically discusses poly(ethylene glycol) (PEG) hydrogels, which are good for biological applications because they do not generally elicit an immune response. PEGs offer a readily available, easy to modify polymer for widespread use in hydrogel fabrication, including 2D and 3D scaffold for tissue culture. The degradable linkages also enable a variety of applications for release of therapeutic agents.

Versatile Cell Culture Scaffolds: Bio-orthogonal Click

Designing biomaterial scaffolds mimicking complex living tissue structures is crucial for tissue engineering and regenerative medicine advancements.

자사의 과학자팀은 생명 과학, 재료 과학, 화학 합성, 크로마토그래피, 분석 및 기타 많은 영역을 포함한 모든 과학 분야에 경험이 있습니다..

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