900917

N-Azidoacetylmannosamine-tetraacylated

95%

• 동의어(들): Ac₄ManNAz
• 실험식(Hill 표기법): C₁₆H₂₂N₄O₁₀
• CAS Number: 361154-30-5
• Molecular Weight: 430.37
• MDL number: MFCD26961126
• UNSPSC 코드: 12352116
• NACRES: NA.22

속성

• Quality Level: 100
• 분석: 95%
• 양식: powder or crystals
• 반응 적합성: reaction type: click chemistry
• 저장 온도: −20°C
• SMILES string: [N+](=[N-])=NCC(=O)N[C@H]1[C@H]([C@@H]([C@H](OC1OC(=O)C)COC(=O)C)OC(=O)C)OC(=O)C
• InChI: 1S/C16H22N4O10/c1-7(21)26-6-11-14(27-8(2)22)15(28-9(3)23)13(16(30-11)29-10(4)24)19-12(25)5-18-20-17/h11,13-16H,5-6H2,1-4H3,(H,19,25)/t11-,13+,14-,15-,16?/m1/s1
• InChI key: HGMISDAXLUIXKM-LIADDWGISA-N

설명

애플리케이션

N-Azidoacetylmannosamine-tetraacylated (Ac₄ManNAz) is an azide-containing metabolic glycoprotein labeling reagent that can be incorporated into the sialic acid biosynthesis pathway. The azide-modified protein can be detected by reaction with alkynes. For example alkynes labeled with a fluorescent probe or a biotin can be used. The acetyl groups increase cell permeability and allow the unnatural sugars to easily pass through the cell membrane. Carboxyesterases remove the acetyl groups once the monosaccharide is in the cell.

Tetraacylated N-azidoacetylmannosamine is generally used in click chemistry applications in bioconjugate chemistry.

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable