800812C

12:0 DG

1,2-dilauroyl-sn-glycerol, chloroform

• 동의어(들): 1,2-didodecanoyl-sn-glycerol; DG(12:0/12:0/0:0); 110611
• 실험식(Hill 표기법): C₂₇H₅₂O₅
• CAS Number: 60562-15-4
• Molecular Weight: 456.70
• UNSPSC 코드: 12352211
• NACRES: NA.25

속성

• 분석: >99% (TLC)
• 형태: liquid
• 포장: pkg of 2 × 4 mL (800812C-200mg); pkg of 1 × 5 mL (800812C-10mg)
• 제조업체/상표: Avanti Research^™ - A Croda Brand 800812C
• 농도: 2 mg/mL (800812C-10mg); 25 mg/mL (800812C-200mg)
• 지질 유형: neutral lipids; neutral glycerides
• 배송 상태: dry ice
• 저장 온도: −20°C
• InChI: 1S/C27H52O5/c1-3-5-7-9-11-13-15-17-19-21-26(29)31-24-25(23-28)32-27(30)22-20-18-16-14-12-10-8-6-4-2/h25,28H,3-24H2,1-2H3/t25-/m0/s1
• InChI key: OQQOAWVKVDAJOI-VWLOTQADSA-N

설명

일반 설명

sn-1,2-diacylglycerols comprise short saturated acyl side chains (C4-C10) and 12:0 DG is also called 1,2-dilauroyl-sn-glycerol.

애플리케이션

12:0 DG may be used:

• as an internal standard for spiking serum samples for liquid chromatography–mass spectrometry analysis.
• as an internal standard for spiking RAW 264.7 cells for mass spectroscopy studies
• as standard in reverse-phase liquid chromatography coupled mass spectrometer for lipidomics studies of human plasma and serum samples

생화학적/생리학적 작용

sn-1,2-Diacylglycerols are prime regulators of biological functions, especially in platelets. They also activate protein kinase C. 1,2-dilauroyl-sn-glycerol is a polymerization initiator used in the synthesis of (R)-3-((2-bromo-2-methylpropanoyl)oxy)propane-1,2-diyl didodecanoate (BMPD).

포장

30 mL Amber Narrow Mouth Glass Bottle with Screw Cap (800812C-10mg)

30 mL Amber Narrow Mouth Glass Bottle with Screw Cap (800812C-200mg)

저장 및 안정성

Diacylglycerols are conveniently stored in chloroform solutions in glass vials with PTFE-lined caps at -20°C. Under these conditions acyl migration is minimal. Avoid plastic when handling chloroform solutions.

기타 정보

Delivery to cells:
Dry samples of diacylglycerol in chloroform, using a stream of nitrogen. Dissolve the residue in an appropriate volume of ethanol or DMSO, then dilute to the desired aqueous medium.

Effective concentration:
Most biological responses saturate at 20 to 250 μM sn-1,2-dioctanoylglycerol. Only sn-1,2 isomers appear to be active.

Precaution: Since short chain Diacylglycerols mimic effects of the tumor-promoting phorbol diesters in a number of biological systems, extra care should be employed in their handling. Treatment of solutions, vessels and other articles with 1N NaOH before washing or discarding will destroy diacylglycerols.

법적 정보

Avanti Research is a trademark of Avanti Polar Lipids, LLC

안전성 정보

• 픽토그램: GHS06,GHS08
• 신호어: Danger
• 유해 및 위험 성명서: H302,H315,H319,H331,H336,H351,H361d,H372
• 예방조치 성명서: P202 - P301 + P312 - P302 + P352 - P304 + P340 + P311 - P305 + P351 + P338 - P308 + P313
• Hazard Classifications: Acute Tox. 3 Inhalation - Acute Tox. 4 Oral - Carc. 2 - Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2 - STOT RE 1 Oral - STOT SE 3
• 표적 기관: Central nervous system, Liver,Kidney
• Storage Class Code: 6.1D - Non-combustible acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects
• WGK: WGK 3
• Flash Point (°F): does not flash
• Flash Point (°C): does not flash