480066
Necrostatin-1, Inactive Control
A cell-permeable N-demethylated thiohydantoin analog of Nec-1 that is devoid of anti-necroptotic properties and serves as a suitable inactive control.
동의어(들):
Necrostatin-1, Inactive Control, 5-(Indol-3-ylmethyl)-2-thiohydantoin, Nec-1i
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모든 사진(1)
About This Item
추천 제품
Quality Level
분석
≥95% (HPLC)
형태
crystalline solid
제조업체/상표
Calbiochem®
저장 조건
OK to freeze
protect from light
색상
light yellow
solubility
DMSO: 10 mg/mL
methanol: 5 mg/mL
배송 상태
ambient
저장 온도
2-8°C
InChI
1S/C12H11N3OS/c16-11-10(14-12(17)15-11)5-7-6-13-9-4-2-1-3-8(7)9/h1-4,6,10,13H,5H2,(H2,14,15,16,17)
InChI key
MPLRRPKKFHUEEL-UHFFFAOYSA-N
일반 설명
A cell-permeable N-demethylated thiohydantoin analog of Nec-1 (Cat. No. 480065) that is devoid of anti-necroptotic properties and serves as a suitable inactive control.
Note: This inactive inhibitor of necrosis should not be used in high concentration.
Note: This inactive inhibitor of necrosis should not be used in high concentration.
A cell-permeable N-demethylated thiohydantoin analog of Nec-1 (Cat. No. 480065) that is devoid of anti-necroptotic properties and serves as a suitable inactive control.
Note: This inactive inhibitor of necrosis should not be used in high concentration.
Note: This inactive inhibitor of necrosis should not be used in high concentration.
생화학적/생리학적 작용
Cell permeable: yes
Primary Target
Inactive control for Nec-1 (Cat. No. 480065)
Inactive control for Nec-1 (Cat. No. 480065)
Product does not compete with ATP.
Reversible: no
포장
Packaged under inert gas
경고
Toxicity: Standard Handling (A)
재구성
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
기타 정보
Takahashi et al. 2012. Cell Death and Disease3, e437.
Degterev, A., et al. 2005. Nat. Chem. Biol.1, 112.
Degterev, A., et al. 2005. Nat. Chem. Biol.1, 112.
법적 정보
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Storage Class Code
11 - Combustible Solids
WGK
WGK 1
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
시험 성적서(COA)
제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.
Cell death & disease, 3, e437-e437 (2012-11-30)
Necrostatin-1 (Nec-1) is widely used in disease models to examine the contribution of receptor-interacting protein kinase (RIPK) 1 in cell death and inflammation. We studied three Nec-1 analogs: Nec-1, the active inhibitor of RIPK1, Nec-1 inactive (Nec-1i), its inactive variant
Nature chemical biology, 1(2), 112-119 (2006-01-13)
The mechanism of apoptosis has been extensively characterized over the past decade, but little is known about alternative forms of regulated cell death. Although stimulation of the Fas/TNFR receptor family triggers a canonical 'extrinsic' apoptosis pathway, we demonstrated that in
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