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Merck
모든 사진(1)

주요 문서

480066

Sigma-Aldrich

Necrostatin-1, Inactive Control

A cell-permeable N-demethylated thiohydantoin analog of Nec-1 that is devoid of anti-necroptotic properties and serves as a suitable inactive control.

동의어(들):

Necrostatin-1, Inactive Control, 5-(Indol-3-ylmethyl)-2-thiohydantoin, Nec-1i

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About This Item

실험식(Hill 표기법):
C12H11N3OS
CAS Number:
Molecular Weight:
245.30
UNSPSC 코드:
12352200
NACRES:
NA.77

Quality Level

분석

≥95% (HPLC)

형태

crystalline solid

제조업체/상표

Calbiochem®

저장 조건

OK to freeze
protect from light

색상

light yellow

solubility

DMSO: 10 mg/mL
methanol: 5 mg/mL

배송 상태

ambient

저장 온도

2-8°C

InChI

1S/C12H11N3OS/c16-11-10(14-12(17)15-11)5-7-6-13-9-4-2-1-3-8(7)9/h1-4,6,10,13H,5H2,(H2,14,15,16,17)

InChI key

MPLRRPKKFHUEEL-UHFFFAOYSA-N

일반 설명

A cell-permeable N-demethylated thiohydantoin analog of Nec-1 (Cat. No. 480065) that is devoid of anti-necroptotic properties and serves as a suitable inactive control.

Note: This inactive inhibitor of necrosis should not be used in high concentration.
A cell-permeable N-demethylated thiohydantoin analog of Nec-1 (Cat. No. 480065) that is devoid of anti-necroptotic properties and serves as a suitable inactive control.



Note: This inactive inhibitor of necrosis should not be used in high concentration.

생화학적/생리학적 작용

Cell permeable: yes
Primary Target
Inactive control for Nec-1 (Cat. No. 480065)
Product does not compete with ATP.
Reversible: no

포장

Packaged under inert gas

경고

Toxicity: Standard Handling (A)

재구성

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

기타 정보

Takahashi et al. 2012. Cell Death and Disease3, e437.
Degterev, A., et al. 2005. Nat. Chem. Biol.1, 112.

법적 정보

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class Code

11 - Combustible Solids

WGK

WGK 1

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable


시험 성적서(COA)

제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.

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문서 라이브러리 방문

N Takahashi et al.
Cell death & disease, 3, e437-e437 (2012-11-30)
Necrostatin-1 (Nec-1) is widely used in disease models to examine the contribution of receptor-interacting protein kinase (RIPK) 1 in cell death and inflammation. We studied three Nec-1 analogs: Nec-1, the active inhibitor of RIPK1, Nec-1 inactive (Nec-1i), its inactive variant
Alexei Degterev et al.
Nature chemical biology, 1(2), 112-119 (2006-01-13)
The mechanism of apoptosis has been extensively characterized over the past decade, but little is known about alternative forms of regulated cell death. Although stimulation of the Fas/TNFR receptor family triggers a canonical 'extrinsic' apoptosis pathway, we demonstrated that in

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