55952
Fusaric acid
derivatization grade (HPLC), ≥99.0% (HPLC)
동의어(들):
5-Butylpicolinic acid, 5-Butylpyridine-2-carboxylic acid
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크기 선택
제품정보 (DICE 배송 시 비용 별도)
실험식(Hill 표기법):
C10H13NO2
CAS 번호:
Molecular Weight:
179.22
EC Number:
208-643-0
UNSPSC Code:
12352204
NACRES:
NA.22
Beilstein/REAXYS Number:
125804
MDL number:
제품 이름
Fusaric acid, derivatization grade (HPLC), ≥99.0% (HPLC)
InChI key
DGMPVYSXXIOGJY-UHFFFAOYSA-N
InChI
1S/C10H13NO2/c1-2-3-4-8-5-6-9(10(12)13)11-7-8/h5-7H,2-4H2,1H3,(H,12,13)
SMILES string
CCCCc1ccc(nc1)C(O)=O
grade
derivatization grade (HPLC)
assay
≥99.0% (HPLC)
technique(s)
HPLC: suitable
Quality Level
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Application
Fusaric acid may be used as a derivatizing reagent for the quantification of hydroxysteroids and dehydroepiandrosterone (DHEA) and sulfated DHEA in biological samples using liquid chromatography electrospray-ionization-tandem mass spectrometry (LC/ESI-MS/MS) technique.
General description
Fusaric acid is a novel proton-affinitive derivatizing agent, having an ionization moiety and a hydrophobic moiety. It is commonly used for the derivatization of alcohols and phenols, by liquid chromatography coupled with electrospray ionization tandem mass spectrometry (LC/ESI-MS/MS).
Chemical derivatization to enhance ionization of anabolic steroids in LC-MS for doping-control analysis
I. Athanasiadou et all.
TrAC, Trends in Analytical Chemistry, 42, 137-156 (2013)
Sevcan Mamur et al.
Drug and chemical toxicology, 43(2), 149-157 (2018-09-12)
Fusaric acid (FA) is produced by several Fusarium species and is commonly found in grains. This investigation was performed to evaluate the cytotoxic and genotoxic effects of FA either in human cervix carcinoma (HeLa) cell line using 3-(4,5-dimethylthiazolyl-2)-2,5 diphenyltetrazolium bromide
Kouwa Yamashita et al.
Journal of the American Society for Mass Spectrometry, 21(2), 249-253 (2009-11-17)
A highly sensitive derivatization method for liquid chromatography (LC)-electrospray ionization (ESI) tandem mass spectrometry of dehydroepiandrosterone (DHEA), testosterone (T), pregnenolone (P5), and 17alpha-OH-pregnenolone (17-OHP5) was developed based on the use of fusaric acid as a reagent. DHEA, P5, and 17-OHP5
T Santa
Drug discoveries & therapeutics, 7(1), 9-17 (2013-03-26)
Liquid chromatography coupled with electrospray ionization tandem mass spectrometry (LC/ESI-MS/MS) has been frequently utilized for the sensitive and selective determination of the trace level compounds in biological samples. In LC/ESI-MS/MS, chemical derivatization is sometimes used to enhance the detection sensitivity
Yasuhiro Shibata et al.
The Journal of steroid biochemistry and molecular biology, 145, 193-199 (2014-05-06)
A reliable and sensitive method for analyzing steroids using liquid chromatography tandem mass spectrometry (LC-MS/MS) is required for research concerning dehydroepiandrosterone (DHEA), which plays a central role in steroid hormone biosynthesis and metabolism. Furthermore, after the first proposal of the
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