모든 사진(1)
About This Item
실험식(Hill 표기법):
C27H26N4O2
CAS Number:
Molecular Weight:
438.52
MDL number:
UNSPSC 코드:
12352111
PubChem Substance ID:
NACRES:
NA.77
추천 제품
생물학적 소스
synthetic (organic)
Quality Level
분석
≥97% (Mixture of 2 isomers)
양식
powder
solubility
DMSO: soluble
ethanol: soluble
배송 상태
dry ice
저장 온도
−20°C
SMILES string
CN1CCCC1CCn2cc(C3=C(C(=O)NC3=O)c4c[nH]c5ccccc45)c6ccccc26
InChI
1S/C27H26N4O2/c1-30-13-6-7-17(30)12-14-31-16-21(19-9-3-5-11-23(19)31)25-24(26(32)29-27(25)33)20-15-28-22-10-4-2-8-18(20)22/h2-5,8-11,15-17,28H,6-7,12-14H2,1H3,(H,29,32,33)
InChI key
LBFDERUQORUFIN-UHFFFAOYSA-N
애플리케이션
Bisindolylmaleimide II (BIS II) has been used:
- as a protein kinase C (PKC) inhibitor to study its effects on cardiomyocyte phenotypes
- as a PKC inhibitor along with methanandamide (mAEA) to study its effects on murine gastric vagal afferent (GVA) mechanosensitivity
- as a PKC/protein kinase A (PKA) inhibitor to study its effects on bone-marrow cells
생화학적/생리학적 작용
Bisindolylmaleimide II (BIS II) acts as a dual protein kinase A/C (PKA/C) inhibitor.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
개인 보호 장비
Eyeshields, Gloves, type N95 (US)
S E Wang et al.
Oncogene, 29(23), 3335-3348 (2010-04-13)
Activating mutations in the tyrosine kinase domain of HER2 (ErbB2) have been identified in human cancers. Compared with wild-type HER2, mutant HER2 shows constitutively activate kinase activity and increased oncogenicity. Cells transformed by mutant HER2 are resistant to epidermal growth
Xiaojie Shi et al.
Brain research bulletin, 130, 138-145 (2017-01-25)
Carnosine is believed to be neuroprotective in cerebral ischemia. However, few reports concern its function on senescent astrocytes during cerebral ischemia. The aim of this study was to investigate the effects of carnosine on cell damage and glutamine synthetase (GS)
Ameneh Cheshmehkani et al.
Biochemical pharmacology, 146, 139-150 (2017-09-26)
Agonism of the G protein-coupled free-fatty acid receptor-4 (FFA4) has been shown to promote numerous anti-inflammatory effects in macrophages that arise due to interaction with β-arrestin partner proteins. Humans express functionally distinct short and long FFA4 splice variants, such that
Binh Thanh Nguyen et al.
Electrophoresis, 37(23-24), 3146-3153 (2016-10-27)
An assay for protein kinase C delta (PKCδ) activity based on the quantification of a synthetic substrate using capillary electrophoresis with laser-induced fluorescence detection was developed. The peptides labeled with fluorescein isothiocyanate F-ERK (where ERK is extracellular signal-regulated kinase) and
Salome Boroda et al.
Biochemical pharmacology, 123, 29-39 (2016-12-16)
Diacylglycerol kinase alpha (DGKα) catalyzes the conversion of diacylglycerol (DAG) to phosphatidic acid (PA). Recently, DGKα was identified as a therapeutic target in various cancers, as well as in immunotherapy. Application of small-molecule DGK inhibitors, R59022 and R59949, induces cancer
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