추천 제품
Quality Level
분석
≥98% (HPLC)
양식
solid
저장 조건
desiccated
solubility
DMSO: ≥10 mg/mL
주관자
Novartis
저장 온도
2-8°C
SMILES string
CC(=O)OCC(CCn1cnc2cnc(N)nc12)COC(C)=O
InChI
1S/C14H19N5O4/c1-9(20)22-6-11(7-23-10(2)21)3-4-19-8-17-12-5-16-14(15)18-13(12)19/h5,8,11H,3-4,6-7H2,1-2H3,(H2,15,16,18)
InChI key
GGXKWVWZWMLJEH-UHFFFAOYSA-N
유사한 제품을 찾으십니까? 방문 제품 비교 안내
애플리케이션
Famciclovir is used in herpes virus infections and hepatitis B drug development research. It may be used as a reference compound. Famciclovir may be used to study the factors that control its conversion into penciclovir and other metabolites.
생화학적/생리학적 작용
Famciclovir is an Antiviral; Guanine analog used to treat herpesvirus infections.
Famciclovir is an antiretroviral guanosine analog used to treat herpesvirus infections and hepatitis B. Famciclovir is rapidly converted to penciclovir. Viral thymidine kinase phosphorylates penciclovir to a monophosphate form that celular kinases convert in turn to penciclovir triphosphate. Penciclovir triphosphate competitively inhibits viral DNA polymerase and thus viral replication. Prolonged administration can lead to resistance; it is often manifested as selection of pre-existing resistant strains with mutations in the reverse transcriptase domain of the DNA polymerase gene.
특징 및 장점
This compound was developed by Novartis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
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시험 성적서(COA)
Lot/Batch Number
Joshua T Schiffer et al.
The Journal of antimicrobial chemotherapy, 66(11), 2593-2600 (2011-08-26)
The presence of herpes simplex virus-2 (HSV-2) shedding episodes correlates with transmission to sexual partners and neonates, and some episodes correlate with disease manifestations. HSV-2-targeted guanosine analogues are effective when given on a prophylactic basis, but do not completely eliminate
Samira Mubareka et al.
Expert opinion on drug safety, 9(4), 643-658 (2010-05-01)
Famciclovir is the prodrug of penciclovir, a guanosine analogue that inhibits viruses of the alpha sub-family of the Herpesviridae, as well as hepatitis B virus. It is indicated for management of mucocutaneous herpes simplex virus disease and acute herpes zoster
Dene Simpson et al.
Drugs, 66(18), 2397-2416 (2006-12-22)
Famciclovir (Famvir) is the oral prodrug of penciclovir, an agent that has demonstrated antiviral activity against herpes simplex viruses, type 1 (HSV-1) and 2 (HSV-2) [which cause orolabial and/or genital herpes simplex], and against varicella zoster virus (VZV) [a reactivation
Stephanie Frisch et al.
Pediatric dermatology, 28(1), 46-52 (2011-01-26)
We present 5 cases of eczema herpeticum in patients with severe recalcitrant atopic dermatitis to illustrate the range of possible clinical findings and supporting laboratory data that can obscure the diagnosis and complicate treatment. Major issues include: the need for
Donald C Vinh et al.
Expert opinion on pharmacotherapy, 7(16), 2271-2286 (2006-10-25)
Herpes simplex virus is one of the most common causes of genital ulcer disease worldwide. Herpes simplex virus-2 is the more common cause of genital herpes, a chronic infection that is characterised by periodic reactivation, with the capacity to produce
문서
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Bioactive small molecules for immune system signaling target identification/validation and antibiotics, antivirals, and antifungals offered.
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