F9890

Anti-Human IgG4−FITC antibody, Mouse monoclonal

clone HP-6025, purified from hybridoma cell culture

• 동의어(들): Monoclonal Anti-Human IgG4
• UNSPSC 코드: 12352203
• NACRES: NA.46

속성

• 생물학적 소스: mouse
• Quality Level: 300
• 결합: FITC conjugate
• 항체 형태: purified from hybridoma cell culture
• 항체 생산 유형: secondary antibodies
• 클론: HP-6025, monoclonal
• 양식: buffered aqueous solution
• 저장 조건: protect from light
• 기술: dot immunobinding: 1:64 using using a 4-8 μg dot of human IgG4
• 동형: IgG1
• 배송 상태: dry ice
• 저장 온도: −20°C
• 타겟 번역 후 변형: unmodified

설명

일반 설명

IgG4 (Immunoglobulin G4) is produced by T helper 2 cytokines.

특이성

Monoclonal Anti-Human IgG4 is specific for the IgG4 subclass and nonreactive with IgG1, IgG2 and IgG3 in an ELISA.

애플리케이션

Monoclonal Anti-Human IgG4-FITC antibody produced in mouse has been used in immunohistofluorescence and immunofluorescence assay.

The IUIS/WHO2 study singled out this monoclonal antibody as one of the most widely applicable IgG4 specific monoclonal antibodies. Monoclonal Anti-Human IgG4 may be used for the identification of the IgG4 subclass by various immunoassays including: ELISA, Imprint Immunofixation (IIF), Immunofluorometric Assay (IFMA), Hemagglutination (HA), Hemagglutination Inhibition (HAI), Particle Counting Immunoassay (PACIA), and detection of cytoplasmic IgG.

생화학적/생리학적 작용

IgG4 (Immunoglobulin G4) antibody has reduced affinity for C1q (first component of complement q) and hence its anti-inflammatory activity differs from that of the other IgG subclasses. IgG4 antibodies are known to actively interchange Fab arms with another molecule, resulting in recombined antibodies with two different binding specificities. This exchange is considered as an important biological mechanism that contributes to its anti-inflammatory activity. IgG4 antibodies are normally noninflammatory, but autoreactive IgG4 antibodies are known to be associated with Immunoglobulin G4 (IgG4)-related disease (IgG4-RD), characterized by infiltrating lymphoplasmacytic cells and elevated serum IgG4.

물리적 형태

Solution in 0.01 M phosphate buffer, pH 8.0, containing 1% inactivated bovine serum albumin and 15 mM sodium azide.

면책조항

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

안전성 정보

• Storage Class Code: 10 - Combustible liquids
• WGK: nwg
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• 개인 보호 장비: Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)