I8409

Anti-Interleukin-7 Receptor α/CD127 antibody produced in goat

affinity isolated antibody, lyophilized powder

• 동의어(들): Anti-CD127, Anti-CDW127, Anti-IL7R, Anti-ILRA
• MDL number: MFCD01864808
• UNSPSC 코드: 51111800
• NACRES: NA.41
• 결합: unconjugated
• application: FACS; WB
• 클론: polyclonal
• 종 반응성: human
• citations: 7
• 기술: flow cytometry: 5.0-10.0 μg/mL; western blot: 0.1-0.2 μg/mL

속성

• 생물학적 소스: goat
• Quality Level: 100
• 결합: unconjugated
• 항체 형태: affinity isolated antibody
• 항체 생산 유형: primary antibodies
• 클론: polyclonal
• 양식: lyophilized powder
• 종 반응성: human
• 기술: flow cytometry: 5.0-10.0 μg/mL; western blot: 0.1-0.2 μg/mL
• UniProt 수납 번호: P16871
• 저장 온도: −20°C
• 타겟 번역 후 변형: unmodified
• 유전자 정보: human ... IL7R(3575)

설명

일반 설명

Interleukin-7 (IL-7) is a stromal-cell derived cytokine that is important in the development of adaptive immunity and maintenance of T cells and B cells. The cognate receptor that binds IL-7 is the IL-7 receptor complex, made up of IL-7 R α chain and a γ chain. The expression of IL-7 R is restricted to immature B cells, mature T cells and thymocytes. The binding of IL-7 to its receptor triggers a variety of tightly regulated signalling pathways that are critical for cell survival, proliferation, differentiation and uptake of glucose. The signalling pathways that participate in mediating the effects of IL-7 R are JAK/STAT and PI3K. Additionally the effect of IL-7 on cell cycle is due to the modulation of proteins p27^kip1 and Cdc25A. Reports implicate IL-7 R in glucose metabolism and cell size as it modulates the effects of GLUT4
Anti-interleukin-7 receptor α/CD127 recognizes human interleukin-7.

면역원

purified, NSO cell-derived recombinant human interleukin-7 soluble receptor α.

애플리케이션

Anti-interleukin-7 receptor α/CD127 antibody may be used for immunoblotting at a working concentration of 0.1-0.2 μg/ml. For flow cytometry, the recommended concentration is 5-10 μg/ml.

표적 설명

Interleukin-7 Receptor α/CD127 encodes a receptor for interleukine 7 (IL7). The function of this receptor requires the interleukin 2 receptor, gamma chain (IL2RG), which is a common gamma chain shared by the receptors of various cytokines, including

물리적 형태

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline containing carbohydrates.

면책조항

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

안전성 정보

• Storage Class Code: 13 - Non Combustible Solids
• WGK: WGK 1
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• 개인 보호 장비: Eyeshields, Gloves, type N95 (US)