P2795

Phytosphingosine hydrochloride

• 동의어(들): 4-Hydroxysphinganine, D-Ribo-1,3,4-trihydroxy-2-aminooctadecane, D-Ribo-2-aminooctadecane-1,3,4-triol, PHS
• 실험식(Hill 표기법): C₁₈H₃₉NO₃ · HCl
• CAS Number: 554-62-1
• Molecular Weight: 353.97
• MDL number: MFCD06804643
• UNSPSC 코드: 12352211
• PubChem Substance ID: 24898363
• NACRES: NA.25

속성

• 양식: powder
• Quality Level: 200
• 환경친화적 대안 제품 점수: old score: 19; new score: 9; Find out more about DOZN™ Scoring
• 환경친화적 대안 제품 특성: Less Hazardous Chemical Syntheses; Safer Solvents and Auxiliaries; Use of Renewable Feedstocks; Learn more about the Principles of Green Chemistry.
• sustainability: Greener Alternative Product
• 환경친화적 대안 카테고리: , Re-engineered
• 지질 유형: sphingolipids
• 저장 온도: −20°C
• SMILES string: Cl.CCCCCCCCCCCCCC[C@@H](O)[C@@H](O)[C@@H](N)CO
• InChI: 1S/C18H39NO3.ClH/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-17(21)18(22)16(19)15-20;/h16-18,20-22H,2-15,19H2,1H3;1H/t16-,17+,18-;/m0./s1
• InChI key: GDKAAHDFPOWGQE-RXQQAGQTSA-N

설명

생화학적/생리학적 작용

Phytosphingosine is a long chain sphingoid base that occurs broadly in yeast, plants and animals including mammals. In yeast it is involved in mediating the heat stress response, perhaps through activation of the AGC-type protein kinases, Pkh1, Pkh2, Ypk1, Ypk2, and Sch9. It is proapoptotic in human cancer cell lines. PHS induces ΔΨ_m and release of cytochrome c from mitochondria either directly or through activation of p38 MAPK pathway. This leads to activation of caspase 9 followed by activation of caspase 3 and programmed cell death.

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 2
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• 개인 보호 장비: Eyeshields, Gloves, type N95 (US)