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Merck
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주요 문서

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S0758

Sigma-Aldrich

Sulfaphenazole

≥98%

동의어(들):

4-Amino-N-(1-phenyl-1H-pyrazol-5-yl)benzenesulfonamide

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About This Item

실험식(Hill 표기법):
C15H14N4O2S
CAS Number:
526-08-9
Molecular Weight:
314.36
EC Number:
208-384-3
MDL number:
MFCD00057226
UNSPSC 코드:
12352204
PubChem Substance ID:
24278198
NACRES:
NA.77
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Quality Level

100

분석

≥98%

양식

powder

solubility

ethanol: 25 mg/mL, clear, colorless to yellow

저장 온도

2-8°C

SMILES string

Nc1ccc(cc1)S(=O)(=O)Nc2ccnn2-c3ccccc3

InChI

1S/C15H14N4O2S/c16-12-6-8-14(9-7-12)22(20,21)18-15-10-11-17-19(15)13-4-2-1-3-5-13/h1-11,18H,16H2

InChI key

QWCJHSGMANYXCW-UHFFFAOYSA-N

유전자 정보

human ... CYP2C18(1562) , CYP2C19(1557) , CYP2C9(1559)

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애플리케이션

Sulfaphenazole has been used as a positive control to inhibit cytochrome P450 2C9 (cyp2c9) to quantify Rhodiola rosea inhibition.[1] It has also been used as cytochrome P450 2C9 (cyp2c9) inhibitor in endothelial cells[2] and microsomal preparations.[3]

생화학적/생리학적 작용

Antibacterial. Specific inhibitor of CYP2C9. Blocks pro-inflammatory and atherogenic effects of linoleic acid (increase in oxidative stress and activation of AP-1) mediated by CYP2C9. Specific inhibitor of CYP2C9. Blocks pro-inflammatory and atherogenic effects of linoleic acid (increase in oxidative stress and activation of AP-1) mediated by CYP2C9. Inhibits bradykinin-induced tPA release.

Storage Class Code

11 - Combustible Solids

WGK

WGK 2

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

개인 보호 장비

Eyeshields, Gloves, type N95 (US)

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시험 성적서(COA)

Lot/Batch Number
0000436070
0000436070
0000368519
0000363184
0000363184

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