SML0036

Procarbazine hydrochloride

≥98% (HPLC)

• 동의어(들): N-(1-Methylethyl)-4-[(2-methylhydrazinyl)methyl]benzamide hydrochloride
• 실험식(Hill 표기법): C₁₂H₁₉N₃O·HCl
• CAS Number: 366-70-1
• Molecular Weight: 257.76
• EC Number: 206-678-6
• MDL number: MFCD00072082
• UNSPSC 코드: 12352200
• PubChem Substance ID: 329825106
• NACRES: NA.77

속성

• 분석: ≥98% (HPLC)
• 양식: powder
• 저장 조건: desiccated
• 색상: white to tan
• solubility: DMSO: ≥18 mg/mL
• 저장 온도: 2-8°C
• SMILES string: Cl.CNNCc1ccc(cc1)C(=O)NC(C)C
• InChI: 1S/C12H19N3O.ClH/c1-9(2)15-12(16)11-6-4-10(5-7-11)8-14-13-3;/h4-7,9,13-14H,8H2,1-3H3,(H,15,16);1H
• InChI key: DERJYEZSLHIUKF-UHFFFAOYSA-N

설명

애플리케이션

Procarbazine hydrochloride has been used to study its physicochemical property.[1]

Procarbazine, an antineoplastic alkylating agent, may be used to study its pharmacokinetics, metabolism, safety, efficacy and methods of delivery as an anticancer agent. It may be used to study new combination of anticancer drugs.

생화학적/생리학적 작용

Procarbazine hydrochloride is a Antineoplastic alkylating agent

Procarbazine is an antineoplastic alkylating agent widely used in cancer chemotherapy in combination with other compounds. It has multiple mechanisms of action. Procarbazine inhibits protein, RNA and DNA synthesis in addition to being an alkylating agent.

Procarbazine is metabolized to azoprocarbazine either by cytochrome P450 enzyme and monoamine oxidase in an NADPH (nicotinamide adenine diphosphate) dependent or independent manner. It is considered neurotoxic.[2] Procarbazine is used in combination with therapy for treating Hodgkin′s disease.[3]

안전성 정보

• 픽토그램: GHS08,GHS07
• 신호어: Danger
• 유해 및 위험 성명서: H302,H341,H350,H360
• 예방조치 성명서: P201 - P301 + P312 + P330 - P308 + P313
• Hazard Classifications: Acute Tox. 4 Oral - Carc. 1B - Muta. 2 - Repr. 1A
• Storage Class Code: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable