추천 제품
Quality Level
분석
≥98% (HPLC)
양식
powder
색상
yellow to orange
solubility
DMSO: ≥10 mg/mL
저장 온도
2-8°C
SMILES string
Cc1cc(\C=C2/SC(=O)N(c3ccccc3)C2=O)c(C)n1-c4cccnc4
InChI
1S/C21H17N3O2S/c1-14-11-16(15(2)23(14)18-9-6-10-22-13-18)12-19-20(25)24(21(26)27-19)17-7-4-3-5-8-17/h3-13H,1-2H3/b19-12-
InChI key
NCSHZXNGQYSKLR-UNOMPAQXSA-N
애플리케이션
iCRT14 may be used in Wnt /β-catenin-mediated cell signaling studies.
생화학적/생리학적 작용
Wnt / beta-catenin pathway inhibitor
iCRT14 belongs to the thiazolidinedione class of β-catenin-responsive transcription inhibitors. It decreases the levels of Dishevelled protein and modulates the binding of T-cell factor (TCF) to DNA. It results in consistent decrease in reduction of cell proliferation and tumor growth in colon cancer cells.
iCRT14 is a Wnt / β-catenin pathway inhibitor. It is a potent inhibitor of Catenin Responsive Transcription (CRT) reporter genes, as well as endogenous gene targets. iCRT14 also disrupts β-catenin-TCF4 interaction in a dose dependent manner, and causes G0/G1 arrest in colon tumor lines.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
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시험 성적서(COA)
Lot/Batch Number
이미 열람한 고객
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International journal of molecular sciences, 20(13) (2019-07-11)
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Sohee Jun et al.
Nature communications, 7, 10994-10994 (2016-03-25)
Despite the implication of Wnt signalling in radioresistance, the underlying mechanisms are unknown. Here we find that high Wnt signalling is associated with radioresistance in colorectal cancer (CRC) cells and intestinal stem cells (ISCs). We find that LIG4, a DNA
Winning WNT: race to Wnt signaling inhibitors.
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Proceedings of the National Academy of Sciences of the United States of America, 108(15), 5929-5930 (2011-04-01)
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