추천 제품
Quality Level
분석
≥98% (HPLC)
양식
powder
색상
yellow to orange
solubility
DMSO: ≥10 mg/mL
저장 온도
2-8°C
SMILES string
Cc1cc(\C=C2/SC(=O)N(c3ccccc3)C2=O)c(C)n1-c4cccnc4
InChI
1S/C21H17N3O2S/c1-14-11-16(15(2)23(14)18-9-6-10-22-13-18)12-19-20(25)24(21(26)27-19)17-7-4-3-5-8-17/h3-13H,1-2H3/b19-12-
InChI key
NCSHZXNGQYSKLR-UNOMPAQXSA-N
애플리케이션
iCRT14 may be used in Wnt /β-catenin-mediated cell signaling studies.
생화학적/생리학적 작용
Wnt / beta-catenin pathway inhibitor
iCRT14 belongs to the thiazolidinedione class of β-catenin-responsive transcription inhibitors. It decreases the levels of Dishevelled protein and modulates the binding of T-cell factor (TCF) to DNA. It results in consistent decrease in reduction of cell proliferation and tumor growth in colon cancer cells.
iCRT14 is a Wnt / β-catenin pathway inhibitor. It is a potent inhibitor of Catenin Responsive Transcription (CRT) reporter genes, as well as endogenous gene targets. iCRT14 also disrupts β-catenin-TCF4 interaction in a dose dependent manner, and causes G0/G1 arrest in colon tumor lines.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
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시험 성적서(COA)
Lot/Batch Number
이미 열람한 고객
Daiana S Sánchez et al.
Biochemical and biophysical research communications, 512(2), 170-175 (2019-03-19)
This work was aimed to determine the effect of 17β-estradiol (17βE) on cell proliferation in human renal tubular epithelial cells (HRTEC) isolated from kidneys from pediatric subjects, as well as the role of estrogen receptors involved in the 17βE proliferative
Winning WNT: race to Wnt signaling inhibitors.
Kazuhide Watanabe et al.
Proceedings of the National Academy of Sciences of the United States of America, 108(15), 5929-5930 (2011-04-01)
The S-G2 phase enriched beta-catenin/TCF complex ensures cell survival and cell cycle progression
Ding Y, et al.
Journal of Cell Science, jcs-146977 (2014)
Xin Wang et al.
Nature communications, 7, 10633-10633 (2016-02-05)
Cancer stem cells (CSCs) contribute to tumour heterogeneity, therapy resistance and metastasis. However, the regulatory mechanisms of cancer cell stemness remain elusive. Here we identify PCNA-associated factor (PAF) as a key molecule that controls cancer cell stemness. PAF is highly
Foster C Gonsalves et al.
Proceedings of the National Academy of Sciences of the United States of America, 108(15), 5954-5963 (2011-03-12)
Misregulated β-catenin responsive transcription (CRT) has been implicated in the genesis of various malignancies, including colorectal carcinomas, and it is a key therapeutic target in combating various cancers. Despite significant effort, successful clinical implementation of CRT inhibitory therapeutics remains a
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