추천 제품
제품명
Thiazovivin, ≥98% (HPLC)
Quality Level
분석
≥98% (HPLC)
양식
powder
색상
, white to beige to brown
solubility
DMSO: 20 mg/mL, clear
저장 온도
−20°C
SMILES string
[s]1c(nc(c1)C(=O)NCc3ccccc3)Nc2ncncc2
InChI
1S/C15H13N5OS/c21-14(17-8-11-4-2-1-3-5-11)12-9-22-15(19-12)20-13-6-7-16-10-18-13/h1-7,9-10H,8H2,(H,17,21)(H,16,18,19,20)
InChI key
DOBKQCZBPPCLEG-UHFFFAOYSA-N
애플리케이션
Thiazovivin has been used in the generation of induced pluripotent stem cells (iPSCs) and induced neural stem cells (iNSCs) from human urine cells. It has also been used to study the the effect of pro-fibrotic inhibition on cardiac reprogramming.
생화학적/생리학적 작용
Thiazovivin is a Rho Kinase (ROCK) inhibitor that promotes the transformation of fibroblasts into stem cells with a 200-fold efficiency over the classic method when used in combination with ALK5 inhibitor SB-431542 (S4317) and MEK inhibitor PD-0325901 (PZ0162). Thiazovivin stabilizes E-cadherin on the cell surface, necessary for human embryonic stem cell survival in culture. When human embryonic stem cells are cut out from the colony, this key protein is disrupted and then internalized within the cell. Without e-cadherin on the cell surface, cell signaling between the cells and their environment is disrupted and the cells quickly die.
Thiazovivin is a Rho Kinase (ROCK) inhibitor.
Thiazovivin is an inhibitor of Rho associated coiled-coil containing protein kinase (ROCK). In vitro studies prove that thiazovivin is efficient in stimulating better morphology, expression of ionic transporter and protein involved in cell adhesion.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
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시험 성적서(COA)
Lot/Batch Number
이미 열람한 고객
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Daniel A Armendariz et al.
eLife, 12 (2023-04-25)
Enhancers orchestrate gene expression programs that drive multicellular development and lineage commitment. Thus, genetic variants at enhancers are thought to contribute to developmental diseases by altering cell fate commitment. However, while many variant-containing enhancers have been identified, studies to endogenously
The ROCK inhibitor, thiazovivin, inhibits human corneal endothelial-to-mesenchymal transition/epithelial-to-mesenchymal transition and increases ionic transporter expression.
Wu Q, et al.
International Journal of Molecular Medicine, 40(4), 1009-1018 (2017)
Generation of Urine Cell-Derived Non-integrative Human iPSCs and iNSCs: A Step-by-Step Optimized Protocol.
Cheng L, et al.
Frontiers in Molecular Neuroscience, 10, 348-348 (2017)
Yonatan R Lewis-Israeli et al.
Journal of visualized experiments : JoVE, (175) (2021-10-05)
The ability to study human cardiac development in health and disease is highly limited by the capacity to model the complexity of the human heart in vitro. Developing more efficient organ-like platforms that can model complex in vivo phenotypes, such
Imen Jebeniani et al.
Methods in molecular biology (Clifton, N.J.), 1994, 71-77 (2019-05-28)
Pluripotent stem cells feature the capacity to differentiate into any somatic cell types including cardiomyocytes. We report a cost-effective and simple protocol for the differentiation of specific ventricular cardiomyocytes. These cells are elongated, do not spontaneously beat, and do not
문서
Naive pluripotent stem cells cultured in vitro using specialized media and inhibitors mimic "ground-state" cells from blastocysts.
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