추천 제품
생물학적 소스
human
Quality Level
재조합
expressed in NSO cells
설명
N-terminal 6X histidine-tagged extracellular domain
분석
>97% (SDS-PAGE)
양식
lyophilized powder
분자량
24 kDa by SDS-PAGE
predicted mol wt ~21 kDa
기술
cell culture | mammalian: suitable
불순물
endotoxin, tested
UniProt 수납 번호
저장 온도
−20°C
유전자 정보
human ... TNFSF10(8743)
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애플리케이션
TRAIL human was used to induce cytotoxicity in A549, a human lung carcinoma cell line.
생화학적/생리학적 작용
TNF-related apoptosis-inducing ligand (TRAIL) is a type II transmembrane protein that belongs to TNF family. It is present in both soluble as well as membrane-bound form and can induce rapid apoptosis of various transformed cell lines but not the normal cells. Additionally, the product can also induces apoptotic cell death in TRAIL-sensitive U343MGcells.
Type II transmembrane protein of the TNF superfamily. Ligand for apoptosis-inducing death receptors DR4 and DR5, decoy receptors DcR1 and DcR2, and osteoprotegerin. Approximately 28% amino acid sequence identity to FAS ligand. Human and mouse TRAIL share 65% sequence identity.
물리적 형태
Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline containing 0.5 mg bovine serum albumin.
분석 메모
Induces cytotoxicity in mouse L-929 cells in the presence of actinomycin D.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
J Sträter et al.
Annals of the New York Academy of Sciences, 915, 162-170 (2001-02-24)
The tumor necrosis factor receptor (TNFR) family is a still-growing group of homologous transmembrane proteins, some of which bear an intracellular "death domain" and are able to directly mediate apoptosis. Apoptosis is induced upon trimerization of the receptors by their
Bich Hang Do et al.
Journal of microbiology and biotechnology, 27(12), 2156-2164 (2017-10-17)
Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is considered as an antitumor agent owing to its ability to induce apoptosis of cancer cells without imparting toxicity toward most normal cells. TRAIL is produced in poor yield because of its insoluble expression
X D Zhang et al.
FEBS letters, 482(3), 193-199 (2000-10-12)
Resistance of normal cells to tumour necrosis factor related apoptosis inducing ligand (TRAIL) induced apoptosis is believed to be mediated by expression of two decoy receptors. Here we show that the expression and localisation of TRAIL receptors (TRAIL-Rs) vary between
W S Simonet et al.
Cell, 89(2), 309-319 (1997-04-18)
A novel secreted glycoprotein that regulates bone resorption has been identified. The protein, termed Osteoprotegerin (OPG), is a novel member of the TNF receptor superfamily. In vivo, hepatic expression of OPG in transgenic mice results in a profound yet nonlethal
Matthew J Coussens et al.
Journal of visualized experiments : JoVE, (58)(58), doi:10-doi:10 (2012-01-05)
RNA interference (RNAi) is an intrinsic cellular mechanism for the regulation of gene expression. Harnessing the innate power of this system enables us to knockdown gene expression levels in loss of gene function studies. There are two main methods for
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