A265

ARL 67156 trisodium salt hydrate

≥98% (HPLC), solid, ecto-ATPase inhibitor

• Synonim(y): 6-N,N-Diethyl-β-γ-dibromomethylene-D-adenosine-5′-triphosphate trisodium salt hydrate, FPL 67156
• Wzór empiryczny (zapis Hilla): C₁₅H₂₁Br₂N₅Na₃O₁₂P₃ · xH₂O
• Numer CAS: 160928-38-1
• Masa cząsteczkowa: 785.05 (anhydrous basis)
• UNSPSC Code: 12352200
• PubChem Substance ID: 24278252
• NACRES: NA.77
• MDL number: MFCD12910436

Właściwości

• Nazwa produktu: ARL 67156 trisodium salt hydrate, ≥98% (HPLC), solid
• SMILES string: O.[Na+].[Na+].[Na+].CCN(CC)c1ncnc2n(cnc12)[C@@H]3O[C@H](COP(O)(=O)OP([O-])(=O)C(Br)(Br)P([O-])([O-])=O)[C@@H](O)[C@H]3O
• InChI: 1S/C15H24Br2N5O12P3.3Na.H2O/c1-3-21(4-2)12-9-13(19-6-18-12)22(7-20-9)14-11(24)10(23)8(33-14)5-32-37(30,31)34-36(28,29)15(16,17)35(25,26)27;;;;/h6-8,10-11,14,23-24H,3-5H2,1-2H3,(H,28,29)(H,30,31)(H2,25,26,27);;;;1H2/q;3*+1;/p-3/t8-,10-,11-,14-;;;;/m1..../s1
• InChI key: UWMONIJVKGTUGE-OPKBHZIBSA-K
• assay: ≥98% (HPLC)
• form: solid
• color: white to off-white
• solubility: H₂O: >20 mg/mL; DMSO: insoluble
• storage temp.: −20°C
• Quality Level: 100
• Gene Information: human ... ENTPD2(954)

Opis

Application

ARL 67156 trisodium salt hydrate has been used:

• to prevent ATP degradation during cerebrospinal fluid extraction
• as an ATPase inhibitor in ATP quantification assay for preventing ATP degradation in cytoplasm and mitochondrion
• as an ecto-ATPase inhibitor to treat cancer cells for ATP release assay

Biochem/physiol Actions

ecto-ATPase inhibitor; prevents metabolism of P₂ purinoceptor agonists.

General description

ARL 67156, a nucleotide/ATP analog is a competitive inhibitor of CD39. This ecto-ATPase inhibitor is presumed to be metabolically stable in biological studies due to its β, γ-dibromomethylene bridge.

ARL-67156 preferentially inhibits the degradation of ADP compared to the degradation of ATP in the murine colon. It is commonly employed to inhibit ATP hydrolysis in tissue preparations.

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Informacja o środkach bezpieczeństwa

• Klasa składowania: 11 - Combustible Solids
• wgk: WGK 3