C8667

Cholesterol

Sigma Grade, ≥99%

• Synonim(y): 3β-Hydroxy-5-cholestene, 5-Cholesten-3β-ol
• Wzór empiryczny (zapis Hilla): C₂₇H₄₆O
• Numer CAS: 57-88-5
• Masa cząsteczkowa: 386.65
• NACRES: NA.77
• PubChem Substance ID: 24893094
• eCl@ss: 39023139
• UNSPSC Code: 12352111
• EC Number: 200-353-2
• MDL number: MFCD00003646
• Beilstein/REAXYS Number: 1915888

Właściwości

• Nazwa produktu: Cholesterol, Sigma Grade, ≥99%
• InChI: 1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9,18-19,21-25,28H,6-8,10-17H2,1-5H3/t19-,21+,22+,23-,24+,25+,26+,27-/m1/s1
• InChI key: HVYWMOMLDIMFJA-DPAQBDIFSA-N
• SMILES string: CC(C)CCC[C@@H](C)[C@H]1CC[C@H]2[C@@H]3CC=C4C[C@@H](O)CC[C@]4(C)[C@H]3CC[C@]12C
• biological source: sheep wool
• grade: Sigma Grade
• assay: ≥99%
• form: powder
• bp: 360 °C (lit.)
• mp: 147-149 °C (lit.)
• solubility: water: soluble 0.00003 g/L at 20 °C
• density: 1.067 g/mL at 25 °C (lit.)
• shipped in: ambient
• storage temp.: −20°C
• Quality Level: 200
• Gene Information: human ... POLA1(5422), TOP2A(7153) ; rat ... Ar(24208), Polb(29240)

Opis

Application

Cholesterol was used to prepare immune-stimulating complexes to enhance cellular and humoral responses. It was incorporated in animal feed to study the effect of cholesterol-rich diet.

Standard for chromatography

Biochem/physiol Actions

Cholesterol is a lipid that makes up about 20-25% of the structural components of the cell membranes. It determines the fluidity and permeability of the membrane, making it permeable to water but not to ions and protons. Cholesterol also regulates the functions of the transporters and signaling proteins present on the plasma membrane. The major sites of cholesterol synthesis are small intestine and liver.

Major component of all biological membranes; ~25% of total brain lipid is cholesterol.

Preparation Note

Cholesterol monohydrate yields a clear, colorless to faint yellow solution in hot alcohol. It is also soluble in acetone, dioxane, ethyl acetate, benzene, petroleum ether, oils, fats, and in aqueous solutions of bile salts. Solutions should be protected from light.

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Informacja o środkach bezpieczeństwa

• Klasa składowania: 11 - Combustible Solids
• wgk: WGK 1
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, type N95 (US)