MilliporeSigma

ADRA2B

adrenoceptor alpha 2B

Synonyms:
ADRA2L1, ADRA2RL1, ADRARL1, ALPHA2BAR, alpha-2BAR
Species:
UniProtKB ID:
Gene ID:
  • Human(151) Summary: Alpha-2-adrenergic receptors are members of the G protein-coupled receptor superfamily. They include 3 highly homologous subtypes: alpha2A, alpha2B, and alpha2C. These receptors have a critical role in regulating neurotransmitter release from sympathetic nerves and from adrenergic neurons in the central nervous system. This intronless gene encodes the alpha2B subtype, which was observed to associate with eIF-2B, a guanine nucleotide exchange protein that functions in regulation of translation. A polymorphic variant of the alpha2B subtype, which lacks 3 glutamic acids from a glutamic acid repeat element, was identified to have decreased G protein-coupled receptor kinase-mediated phosphorylation and desensitization; this polymorphic form is also associated with reduced basal metabolic rate in obese subjects and may therefore contribute to the pathogenesis of obesity. [provided by RefSeq, Aug 2011]
  • Mouse(11552) adrenergic receptor, alpha 2b
  • Rat(24174) adrenoceptor alpha 2B
  • cow(516422) adrenergic, alpha-2B-, receptor
  • naked mole-rat(101701692) adrenoceptor alpha 2B
  • chicken(427631) adrenergic, alpha-2B-, receptor
  • domestic cat(101090432) adrenoceptor alpha 2B
  • domestic guinea pig(100135476) adrenergic receptor, alpha 2b
  • Zebrafish(266751) adrenergic, alpha-2B-, receptor
  • domestic guinea pig(100727868) adrenoceptor alpha 2B
  • dog(611658) adrenergic, alpha-2B-, receptor
  • Horse(100051684) adrenoceptor alpha 2B
  • sheep(100170318) adrenoceptor alpha 2B

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Small Molecule - Agonist

Product Number
Description
Species
p-Iodoclonidine hydrochloride, analytical standard, for drug analysis,
Species
human
Clonidine hydrochloride, solid,
Species
human
(−)-3-(3,4-Dihydroxyphenyl)-2-methyl-L-alanine sesquihydrate, 99%,
Species
human
Guanabenz acetate, United States Pharmacopeia (USP) Reference Standard,
Species
human
Tizanidine hydrochloride, European Pharmacopoeia (EP) Reference Standard,
Species
human

Small Molecule - Antagonist

Product Number
Description
Species
Yohimbine hydrochloride, ≥98% (HPLC), powder,
Species
human
Idazoxan hydrochloride, ,
Species
human
RX 821002 hydrochloride, solid, ≥98% (HPLC),
Species
human
UK 14,304, ,
Species
human
Mirtazapine for system suitability, European Pharmacopoeia (EP) Reference Standard,
Species
human

Antibodies

Product Number
Description
Species Reactivity
Application
Anti-Alpha 2b Adrenergic Receptor, from rabbit, purified by affinity chromatography,
Species Reactivity
human
Application
immunohistochemistry
western blot
Anti-ADRA2B antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Species Reactivity
human
Application
immunohistochemistry
Anti-ADRA2B antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Species Reactivity
human
Application
immunofluorescence

Small Molecule - Blocker

Product Number
Description
Species
Mianserin hydrochloride, ,
Species
human
Agmatine sulfate salt, ≥97%, powder,
Species
human

Small Molecule - Mixed Agonist/Antagonist

Product Number
Description
Species
UK 14,304, ,
Species
human
(−)-Norepinephrine, ≥98%, crystalline,
Species
human, rat

esiRNA

Product Number
Description
Species
MISSION® esiRNA, targeting human ADRA2B,
Species
human