MilliporeSigma

CACNA1D

calcium channel, voltage-dependent, L type, alpha 1D subunit

Synonyms:
CACH3, CACN4, CACNL1A2, CCHL1A2, Cav1.3, SANDD
Species:
UniProtKB ID:
Gene ID:
  • Human(776) Summary: Voltage-dependent calcium channels mediate the entry of calcium ions into excitable cells, and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, and gene expression. Calcium channels are multisubunit complexes composed of alpha-1, beta, alpha-2/delta, and gamma subunits. The channel activity is directed by the pore-forming alpha-1 subunit, whereas the others act as auxiliary subunits regulating this activity. The distinctive properties of the calcium channel types are related primarily to the expression of a variety of alpha-1 isoforms, namely alpha-1A, B, C, D, E, and S. This gene encodes the alpha-1D subunit. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2012]
  • Mouse(12289) calcium channel, voltage-dependent, L type, alpha 1D subunit
  • Rat(29716) calcium channel, voltage-dependent, L type, alpha 1D subunit
  • sheep(101106371) calcium channel, voltage-dependent, L type, alpha 1D subunit
  • domestic cat(101088394) calcium channel, voltage-dependent, L type, alpha 1D subunit
  • Domestic Rabbit(100327259) calcium channel, voltage-dependent, L type, alpha 1D subunit
  • chicken(395895) calcium channel, voltage-dependent, L type, alpha 1D subunit
  • Horse(100051186) calcium channel, voltage-dependent, L type, alpha 1D subunit
  • dog(484724) calcium channel, voltage-dependent, L type, alpha 1D subunit
  • domestic guinea pig(100726255) calcium channel, voltage-dependent, L type, alpha 1D subunit
  • cow(408013) calcium channel, voltage-dependent, L type, alpha 1D subunit
  • naked mole-rat(101714832) calcium channel, voltage-dependent, L type, alpha 1D subunit

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Small Molecule - Allosteric Modulator

Product Number
Description
Species
Gabapentin solution, 10 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®,
Species
human
Gabapentin solution, 1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®,
Species
human
Pregabalin, European Pharmacopoeia (EP) Reference Standard,
Species
human
Gabapentin, European Pharmacopoeia (EP) Reference Standard,
Species
human
Gabapentin, Pharmaceutical Secondary Standard; Certified Reference Material,
Species
human

Small Molecule - Antagonist

Product Number
Description
Species
Felodipine, British Pharmacopoeia (BP) Reference Standard,
Species
human
Felodipine, United States Pharmacopeia (USP) Reference Standard,
Species
human
Felodipine, European Pharmacopoeia (EP) Reference Standard,
Species
human
Nimodipine, British Pharmacopoeia (BP) Reference Standard,
Species
human
Nimodipine for peak identification, European Pharmacopoeia (EP) Reference Standard,
Species
human

Antibodies

Product Number
Description
Species Reactivity
Application
Monoclonal Anti-CACNA1D antibody produced in mouse, clone S48A-9, 1 mg/mL, purified immunoglobulin,
Species Reactivity
human, mouse, rat
Application
immunocytochemistry
immunoprecipitation (IP)

western blot
Anti-CACNA1D antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Species Reactivity
human
Application
immunofluorescence
immunohistochemistry
Anti-Calcium Channel (α1D Subunit) (L-type of Voltage-gated Ca2+ Channel) antibody produced in rabbit, affinity isolated antibody, lyophilized powder,
Species Reactivity
mouse, rat
Application
immunocytochemistry
immunoprecipitation (IP)

western blot

Small Molecule - Blocker

Product Number
Description
Species
Margatoxin, ,
Species
mouse, rat, human
(+)-cis-Diltiazem hydrochloride, ≥99% (HPLC),
Species
human
Nicardipine hydrochloride, powder, ≥98%,
Species
human
Nifedipine, United States Pharmacopeia (USP) Reference Standard,
Species
human
Amlodipine besylate, ≥98% (HPLC),
Species
human

esiRNA

Product Number
Description
Species
MISSION® esiRNA, targeting human CACNA1D,
Species
human