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M8278

Sigma-Aldrich

Margatoxin

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Synonym(s):
MgTx
Empirical Formula (Hill Notation):
C178H286N52O50S7
CAS Number:
Molecular Weight:
4178.95
MDL number:
NACRES:
NA.32

form

powder

Quality Level

storage temp.

−20°C

InChI

1S/C178H286N52O50S7/c1-15-91(7)140(225-172(273)141(92(8)16-2)224-169(270)138(190)96(12)233)171(272)211-114(75-134(189)240)158(259)223-139(90(5)6)170(271)208-107(43-25-31-64-184)153(254)221-125-87-287-283-83-121-161(262)206-111(58-69-281-14)157(258)210-113(74-133(188)239)147(248)194-78-136(242)199-102(38-20-26-59-179)149(250)217-120-82-282-284-84-122(220-156(257)110(54-57-132(187)238)205-150(251)106(42-24-30-63-183)207-166(267)126-44-33-66-228(126)176(277)119(81-232)216-173(274)142(97(13)234)226-165(125)266)163(264)212-115(70-89(3)4)174(275)230-68-35-47-129(230)177(278)229-67-34-46-128(229)168(269)222-124(86-286-285-85-123(219-152(253)105(204-160(120)261)41-23-29-62-182)164(265)213-116(72-99-48-50-101(235)51-49-99)175(276)227-65-32-45-127(227)167(268)214-117(178(279)280)73-100-76-191-88-195-100)162(263)203-103(39-21-27-60-180)148(249)198-95(11)145(246)202-109(53-56-131(186)237)155(256)209-112(71-98-36-18-17-19-37-98)146(247)193-79-137(243)200-108(52-55-130(185)236)154(255)215-118(80-231)159(260)197-93(9)143(244)192-77-135(241)196-94(10)144(245)201-104(151(252)218-121)40-22-28-61-181/h17-19,36-37,48-51,76,88-97,102-129,138-142,231-235H,15-16,20-35,38-47,52-75,77-87,179-184,190H2,1-14H3,(H2,185,236)(H2,186,237)(H2,187,238)(H2,188,239)(H2,189,240)(H,191,195)(H,192,244)(H,193,247)(H,194,248)(H,196,241)(H,197,260)(H,198,249)(H,199,242)(H,200,243)(H,201,245)(H,202,246)(H,203,263)(H,204,261)(H,205,251)(H,206,262)(H,207,267)(H,208,271)(H,209,256)(H,210,258)(H,211,272)(H,212,264)(H,213,265)(H,214,268)(H,215,255)(H,216,274)(H,217,250)(H,218,252)(H,219,253)(H,220,257)(H,221,254)(H,222,269)(H,223,259)(H,224,270)(H,225,273)(H,226,266)(H,279,280)

InChI key

OVJBOPBBHWOWJI-UHFFFAOYSA-N

Gene Information

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1 of 4

This Item
C9915A2202K1514
Sigma-Aldrich

M8278

Margatoxin

ω-Conotoxin GVIA ≥97% (HPLC)

C9915

ω-Conotoxin GVIA

Sigma-Aldrich

A2202

ω-Agatoxin TK

Sigma-Aldrich

K1514

Kurtoxin

form

powder

form

powder

form

powder

form

solid

Gene Information

human ... CACNA1D(776)
mouse ... CACNA1D(12289)
rat ... CACNA1D(29716)

Gene Information

human ... CACNA1B(774)
mouse ... CACNA1B(12287)
rat ... CACNA1B(257648)

Gene Information

human ... CACNA1A(773)
mouse ... CACNA1A(12286)
rat ... CACNA1A(25398)

Gene Information

human ... CACNA1G(8913), CACNA1H(8912), CACNA1I(8911)
mouse ... CACNA1G(12291), CACNA1H(58226), CACNA1I(239556)
rat ... CACNA1G(29717), CACNA1H(114862), CACNA1I(56827)

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

Amino Acid Sequence

Thr-Ile-Ile-Asn-Val-Lys-Cys-Thr-Ser-Pro-Lys-Gln-Cys-Leu-Pro-Pro-Cys-Lys-Ala-Gln-Phe-Gly-Gln-Ser-Ala-Gly-Ala-Lys-Cys-Met-Asn-Gly-Lys-Cys-Lys-Cys-Tyr-Pro-His [Disulfide Bridges: 7-29; 13-34; 17-36]

Biochem/physiol Actions

Margatoxin is an α-KTx toxin, which is majorly used in ion channel research. It is a 39-amino acid peptide, which is a specific K(V)1.3 channel voltage-dependent K+ channel blocker. Margatoxin is an immunosuppressant that is isolated from the venom of the scorpion Centruroides margaritatus.

Other Notes

Toxin in Centruroides margaritatus (scorpion)

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)


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Margatoxin is a non-selective inhibitor of human Kv1.3 K+ channels.
Bartok A
Toxicon, 87, 6-16 (2014)
H Ouadid-Ahidouch et al.
FEBS letters, 459(1), 15-21 (1999-10-06)
Voltage-dependent K(+) channels were identified and characterized in primary culture of rat prostate epithelial cells. A voltage-dependent, inactivating K(+) channel was the most commonly observed ion channel in both lateral and dorsal cells. The K(+) current exhibited a voltage threshold
M Garcia-Calvo et al.
The Journal of biological chemistry, 268(25), 18866-18874 (1993-09-05)
A novel peptidyl inhibitor of K+ channels has been purified to homogeneity from venom of the new world scorpion Centruroides margaritatus. The primary structure of this 39-amino-acid peptide, which we term margatoxin (MgTX), was determined by amino acid compositional analysis
Anna-Lena Unterweger et al.
Journal of Crohn's & colitis, 15(11), 1943-1958 (2021-04-24)
The potassium channel Kv1.3 is a potentially attractive therapeutic target in T cell-mediated inflammatory diseases, as the activity of antigen-activated T cells is selectively impeded by Kv1.3 inhibition. In this study, we examined Kv1.3 as a potential therapeutic intervention point
Gergely Toldi et al.
Immunobiology, 218(3), 311-316 (2012-06-19)
The transient increase of the cytoplasmic free calcium level plays a key role in the process of lymphocyte activation. Kv1.3 and IKCa1 potassium channels are important regulators of the maintenance of calcium influx during lymphocyte activation and present a possible

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