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A9525

Sigma-Aldrich

Angiotensin II human

≥93% (HPLC), powder

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Synonym(s):
1-8-AngiotensinI, 5-Isoleucine-angiotensinII, Ang II, Angiotensin 2, Angiotensin II, DRVYIHPF, Hypertensin, Ile(5)-angiotensinII
Empirical Formula (Hill Notation):
C50H71N13O12
CAS Number:
Molecular Weight:
1046.18
eCl@ss:
42020611
PubChem Substance ID:
NACRES:
NA.32

biological source

synthetic

Quality Level

Assay

≥93% (HPLC)

form

powder

storage condition

(Keep container tightly closed in a dry and well-ventilated place)

concentration

≤100%

technique(s)

cell culture | mammalian: suitable

impurities

1.2-10.4% acetate

solubility

water: 25 mg/mL, clear, colorless

UniProt accession no.

storage temp.

−20°C

InChI

1S/C50H71N13O12/c1-5-28(4)41(47(72)59-36(23-31-25-54-26-56-31)48(73)63-20-10-14-38(63)45(70)60-37(49(74)75)22-29-11-7-6-8-12-29)62-44(69)35(21-30-15-17-32(64)18-16-30)58-46(71)40(27(2)3)61-43(68)34(13-9-19-55-50(52)53)57-42(67)33(51)24-39(65)66/h6-8,11-12,15-18,25-28,33-38,40-41,64H,5,9-10,13-14,19-24,51H2,1-4H3,(H,54,56)(H,57,67)(H,58,71)(H,59,72)(H,60,70)(H,61,68)(H,62,69)(H,65,66)(H,74,75)(H4,52,53,55)/t28-,33-,34-,35-,36-,37-,38-,40-,41?/m0/s1

InChI key

CZGUSIXMZVURDU-GYGDIBSWSA-N

Gene Information

human ... AGT(183)

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This Item
A9650SAB4200886SAB4200885
Angiotensin II human ≥93% (HPLC), powder

Sigma-Aldrich

A9525

Angiotensin II human

assay

≥93% (HPLC)

assay

≥90% (HPLC)

assay

-

assay

-

form

powder

form

powder

form

buffered aqueous solution, liquid

form

buffered aqueous solution, liquid

storage condition

(Keep container tightly closed in a dry and well-ventilated place)

storage condition

(Keep container tightly closed in a dry and well-ventilated place)

storage condition

-

storage condition

-

concentration

≤100%

concentration

-

concentration

~1 mg/mL

concentration

~1 mg/mL

technique(s)

cell culture | mammalian: suitable

technique(s)

cell culture | mammalian: suitable

technique(s)

-

technique(s)

-

Amino Acid Sequence

Asp-Arg-Val-Tyr-Ile-His-Pro-Phe

General description

Research area: Cell Signaling

Application

  • Angiotensin II (angII) human has been used:
  • to study its effect on interleukin-1β–mediated islet inflammation and β-cell dysfunction.
  • to determine if angII activates specific calcineurin-dependent NFAT (nuclear factor of activated T-cells) isoforms in cardiomyocytes.
  • to study the actions of systemic angII infusions on glomerular permeability in vivo.
  • to induce abdominal aortic aneurysms (AAAs) in ApoE knockout mice for experimental studies.
  • to study the effect of Ang II infusion on atrial branched-chain amino acids (BCAAs) catabolism in male C57/BL6 mice.
  • to check the effects of angII on plasma triglyceride production and its association with insulin resistance in normal rats.

Biochem/physiol Actions

Angiotensin II (angII) is an octapeptide cardiovascular hormone which affects the activities of the heart, kidney, vasculature and brain. AngII in the blood is produced from angiotensinogen via renin and angiotensin converting enzyme (ACE). It works via binding to specific receptors present on cell membranes. It is associated with vasoconstriction, induction of vascular smooth muscle cell growth, stimulation of protooncogene expression, and modulation of myocardial hypertrophy, renal failure and fibrosisAngII plays a key role in the regulation of blood pressure via the renin-angiotensin-aldosterone (RAAS) pathway.

Features and Benefits

The purity of our angiotensin II human, Ang II, is verified to assure your experimental success (HPLC and peptide content). The peptide sequence is DRVYIHPF.

Antibody Adsorbant

Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-OH · 2CH3COOH · H2O

Analysis Note

Peptide content not less than 75%

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Angiotensin II regulates the expression of plasminogen activator inhibitor-1 in cultured endothelial cells. A potential link between the renin-angiotensin system and thrombosis.
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The Journal of Clinical Investigation, 95, 995-995 (1995)
Angiotensin II as a pro-inflammatory mediator.
Phillips MI and Kagiyama S
Current Opinion in Investigational Drugs, 3, 569-569 (2002)
Angiotensin II-forming pathways in normal and failing human hearts.
Urata H et al.
Circulation Research, 66, 883-883 (1990)
Angiotensin II and renal fibrosis.
Mezzano SA et al.
Hypertension, 38, 635-635 (2001)
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