MilliporeSigma

CDK6

cyclin-dependent kinase 6

Synonyms:
PLSTIRE
Species:
UniProtKB ID:
Gene ID:
  • Human(1021) Summary: The protein encoded by this gene is a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of Saccharomyces cerevisiae cdc28, and Schizosaccharomyces pombe cdc2, and are known to be important regulators of cell cycle progression. This kinase is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression and G1/S transition. The activity of this kinase first appears in mid-G1 phase, which is controlled by the regulatory subunits including D-type cyclins and members of INK4 family of CDK inhibitors. This kinase, as well as CDK4, has been shown to phosphorylate, and thus regulate the activity of, tumor suppressor protein Rb. Expression of this gene is up-regulated in some types of cancer. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Nov 2009]
  • Mouse(12571) cyclin-dependent kinase 6
  • Rat(114483) cyclin-dependent kinase 6
  • domestic guinea pig(100732773) cyclin-dependent kinase 6
  • naked mole-rat(101719908) cyclin-dependent kinase 6
  • Domestic Rabbit(100009040) cyclin-dependent kinase 6
  • sheep(100144761) cyclin-dependent kinase 6
  • Horse(100061625) cyclin-dependent kinase 6
  • cow(511754) cyclin-dependent kinase 6
  • dog(609920) cyclin-dependent kinase 6
  • domestic cat(100037415) cyclin-dependent kinase 6
  • chicken(420558) cyclin-dependent kinase 6
  • Zebrafish(100034507) cyclin-dependent kinase 6

Custom & Knockdown Gene Products

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  • Custom Gene Products

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Antibodies

Product Number
Description
Species Reactivity
Application
Anti-phospho-CDK6 (pTyr13) antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human, mouse, rat
Application
immunofluorescence
immunohistochemistry
Monoclonal Anti-CDK6 antibody produced in mouse, clone 8H4, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human, mouse, rat
Application
ELISA
immunofluorescence

immunohistochemistry

proximity ligation assay

western blot
Anti-CDK6 antibody produced in rabbit, affinity isolated antibody, buffered aqueous glycerol solution,
Species Reactivity
human
Application
immunofluorescence
immunohistochemistry

western blot
Anti-CDK6 (Ab-13) antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human, mouse
Application
immunofluorescence
immunohistochemistry
Anti-CDK6 (Ab-24) antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human, mouse, rat
Application
immunohistochemistry
western blot

Small Molecule - Inhibitor

Product Number
Description
Species
Flavopiridol hydrochloride hydrate, ≥98% (HPLC), powder,
Species
human
Kaempferol, ≥97.0% (HPLC),
Species
human, mouse
Kaempferol, ≥90% (HPLC), powder,
Species
human, mouse
Luteolin, ≥98% (TLC), powder,
Species
rat, human, mouse
Chrysin, 97%,
Species
human, mouse

Proteins

Product Number
Description
Species
Cdk6/Cyclin D3 Protein, active, 10 µg, Active, N-terminal, His6-tagged full length human Cdk6 complexed with N-terminal GST-tagged full-length human Cyclin D3, for use in Kinase Assays.,
Species
human
CDK6/CyclinD1, active, His/GST tagged human, PRECISIO® Kinase, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution,
Species
human

esiRNA

Product Number
Description
Species
MISSION® esiRNA, targeting mouse Cdk6,
Species
mouse
MISSION® esiRNA, targeting human CDK6,
Species
human