MilliporeSigma

CHRNG

cholinergic receptor, nicotinic, gamma (muscle)

Synonyms:
ACHRG
Species:
UniProtKB ID:
Gene ID:
  • Human(1146) Summary: The mammalian muscle-type acetylcholine receptor is a transmembrane pentameric glycoprotein with two alpha subunits, one beta, one delta, and one epsilon (in adult skeletal muscle) or gamma (in fetal and denervated muscle) subunit. This gene, which encodes the gamma subunit, is expressed prior to the thirty-third week of gestation in humans. The gamma subunit of the acetylcholine receptor plays a role in neuromuscular organogenesis and ligand binding and disruption of gamma subunit expression prevents the correct localization of the receptor in cell membranes. Mutations in this gene cause Escobar syndrome and a lethal form of multiple pterygium syndrome. Muscle-type acetylcholine receptor is the major antigen in the autoimmune disease myasthenia gravis.[provided by RefSeq, Sep 2009]
  • Mouse(11449) cholinergic receptor, nicotinic, gamma polypeptide
  • Rat(25753) cholinergic receptor, nicotinic, gamma (muscle)
  • cow(281689) cholinergic receptor, nicotinic, gamma (muscle)
  • Zebrafish(325080) cholinergic receptor, nicotinic, gamma
  • dog(486163) cholinergic receptor, nicotinic, gamma (muscle)
  • domestic cat(101098733) cholinergic receptor, nicotinic, gamma (muscle)
  • chicken(429151) cholinergic receptor, nicotinic, gamma
  • naked mole-rat(101706620) cholinergic receptor, nicotinic, gamma (muscle)
  • sheep(101102965) cholinergic receptor, nicotinic, gamma (muscle)
  • domestic guinea pig(100733530) cholinergic receptor, nicotinic, gamma (muscle)

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Small Molecule - Agonist

Product Number
Description
Species
Decamethonium bromide, crystalline,
Species
human

Small Molecule - Antagonist

Product Number
Description
Species
Tubocurarine hydrochloride pentahydrate, ≥97%,
Species
human
Pancuronium bromide, ,
Species
human
Vecuronium bromide, United States Pharmacopeia (USP) Reference Standard,
Species
human
Pancuronium bromide, European Pharmacopoeia (EP) Reference Standard,
Species
human
Tubocurarine chloride, United States Pharmacopeia (USP) Reference Standard,
Species
human

Antibodies

Product Number
Description
Species Reactivity
Application
Anti-CHRNG, N-terminal region antibody produced in rabbit, IgG fraction of antiserum,
Species Reactivity
dog, human, rabbit
Application
western blot