MilliporeSigma

GABRA4

gamma-aminobutyric acid (GABA) A receptor, alpha 4

Synonyms:
Species:
UniProtKB ID:
Gene ID:
  • Human(2557) Summary: Gamma-aminobutyric acid (GABA) is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA-A receptors, which are ligand-gated chloride channels. Chloride conductance of these channels can be modulated by agents such as benzodiazepines that bind to the GABA-A receptor. At least 16 distinct subunits of GABA-A receptors have been identified. This gene encodes subunit alpha-4, which is involved in the etiology of autism and eventually increases autism risk through interaction with another subunit, gamma-aminobutyric acid receptor beta-1 (GABRB1). Alternatively spliced transcript variants encoding different isoforms have been found in this gene.[provided by RefSeq, Feb 2011]
  • Mouse(14397) gamma-aminobutyric acid (GABA) A receptor, subunit alpha 4
  • Rat(140675) gamma-aminobutyric acid (GABA) A receptor, alpha 4
  • chicken(422770) gamma-aminobutyric acid (GABA) A receptor, alpha 4
  • cow(282238) gamma-aminobutyric acid (GABA) A receptor, alpha 4
  • dog(482132) gamma-aminobutyric acid (GABA) A receptor, alpha 4
  • sheep(101121776) gamma-aminobutyric acid (GABA) A receptor, alpha 4
  • domestic cat(101098052) gamma-aminobutyric acid (GABA) A receptor, alpha 4
  • domestic guinea pig(100721252) gamma-aminobutyric acid (GABA) A receptor, alpha 4
  • naked mole-rat(101718327) gamma-aminobutyric acid (GABA) A receptor, alpha 4
  • Domestic Rabbit(100339882) gamma-aminobutyric acid (GABA) A receptor, alpha 4

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Small Molecule - Agonist

Product Number
Description
Species
Gaboxadol hydrochloride, solid, ≥98% (HPLC),
Species
human
Muscimol hydrobromide, ≥98% (HPLC), solid,
Species
human
Piperidine-4-sulfonic acid, ,
Species
human
Isoguvacine hydrochloride, solid,
Species
human
Meprobamate solution, 1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®,
Species
human

Small Molecule - Allosteric Modulator

Product Number
Description
Species
Dehydroisoandrosterone 3-sulfate sodium salt dihydrate, ≥93% (TLC), powder,
Species
human
3α,21-Dihydroxy-5α-pregnan-20-one, ≥95%,
Species
human
5α-Pregnan-3α-ol-11,20-dione, powder, ≥98% (TLC),
Species
human
trans-Dehydroandrosterone, ≥99%,
Species
human, rat
Oxazepam, European Pharmacopoeia (EP) Reference Standard,
Species
human

Small Molecule - Antagonist

Product Number
Description
Species
Picrotoxin, powder,
Species
human
Pregnenolone sulfate sodium salt, ,
Species
human
SR-95531, ≥98% (HPLC), powder,
Species
human
3α,21-Dihydroxy-5α-pregnan-20-one, ≥95%,
Species
human
trans-Dehydroandrosterone, ≥99%,
Species
human, rat

Antibodies

Product Number
Description
Species Reactivity
Application
Anti-GABRA4 antibody produced in goat, affinity isolated antibody, buffered aqueous solution,
Species Reactivity
bovine, human
Application
ELISA
immunohistochemistry

western blot
Monoclonal Anti-GABA A Receptor-Atto 390 antibody produced in mouse, clone S398A-34,
Species Reactivity
human, mouse
Application
immunofluorescence
western blot
Monoclonal Anti-GABA A Receptor-Horseradish Peroxidase antibody produced in mouse, clone S398A-34,
Species Reactivity
human, mouse
Application
immunofluorescence
western blot
Monoclonal Anti-GABA A Receptor-Atto 594 antibody produced in mouse, clone S398A-34,
Species Reactivity
human, mouse
Application
immunofluorescence
western blot
Monoclonal Anti-GABA A Receptor-FITC antibody produced in mouse, clone S398A-34,
Species Reactivity
human, mouse
Application
immunofluorescence
western blot

Small Molecule - Inhibitor

Product Number
Description
Species
NO-711 hydrochloride, ≥98% (HPLC),
Species
human
(±)-Vigabatrin, ,
Species
human
2,6-Diisopropylphenol, 97%,
Species
human
Topiramate solution, 1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®,
Species
human
Topiramate, European Pharmacopoeia (EP) Reference Standard,
Species
human

Small Molecule - Ligand

Product Number
Description
Species
Etomidate, >98% (HPLC), powder,
Species
human
Flumazenil, >99% (HPLC), solid,
Species
rat, human
Carbamazepine, powder,
Species
rat, human
2-Bromo-2-chloro-1,1,1-trifluoroethane, ≥99%,
Species
human

esiRNA

Product Number
Description
Species
MISSION® esiRNA, targeting mouse Gabra4,
Species
mouse
MISSION® esiRNA, targeting human GABRA4,
Species
human