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P9159

Sigma-Aldrich

Piperidine-4-sulfonic acid

Synonym(s):

P4S

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About This Item

Empirical Formula (Hill Notation):
C5H11NO3S
CAS Number:
72450-62-5
Molecular Weight:
165.21
MDL number:
MFCD00055097
UNSPSC Code:
12352106
PubChem Substance ID:
24278165
NACRES:
NA.77

form

powder

SMILES string

OS(=O)(=O)C1CCNCC1

InChI

1S/C5H11NO3S/c7-10(8,9)5-1-3-6-4-2-5/h5-6H,1-4H2,(H,7,8,9)

InChI key

UGBJGGRINDTHIH-UHFFFAOYSA-N

Gene Information

human ... GABRA1(2554) , GABRA2(2555) , GABRA3(2556) , GABRA4(2557) , GABRA5(2558) , GABRA6(2559) , GABRB1(2560) , GABRB2(2561) , GABRB3(2562)

Biochem/physiol Actions

GABAA receptor agonist.

Features and Benefits

This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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E Galvez-Ruano et al.
Journal of neuroscience research, 42(5), 666-673 (1995-12-01)
Based on our molecular modeling investigations of the glycinergic receptor, we expanded our studies to similarly investigate the GABAergic receptor. New data suggest there may exist a slightly different agonistic mechanism for the molecules described herein as compared to glycine.
Angelo Keramidas et al.
The Journal of physiology, 575(Pt 1), 11-22 (2006-06-10)
The binding of the neurotransmitter GABA induces conformational changes in the GABAA receptor (GABAAR), leading to the opening of a gate that controls ion permeation through an integral transmembrane pore. A number of structural elements within each subunit, located near
Marc C Gielen et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 32(17), 5707-5715 (2012-04-28)
GABA(A) receptors (GABA(A)Rs) composed of αβγ subunits are allosterically modulated by the benzodiazepines (BDZs). Agonists at the BDZ binding site potentiate submaximal GABA responses by increasing the apparent affinity of GABA(A)Rs for GABA. Although BDZs were initially thought to affect
Ko Ko et al.
Journal of medical virology (2020-06-25)
This study aimed to investigate the prevalence trend of hepatitis B virus (HBV) and hepatitis C virus (HCV) infections and their genotype distribution among hemodialysis patients, determining their long-term prognosis and the risk factors to the mortality. This cohort study
B Ebert et al.
Molecular pharmacology, 52(6), 1150-1156 (1997-12-16)
Using human gamma-aminobutyric acid type A (GABAA) receptor subunit combinations, expressed in cell lines and Xenopus laevis oocytes, the pharmacology of a number of ligands interacting directly with the GABA recognition site has been studied in [3H]muscimol binding and electrophysiologically.
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