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H1384

Sigma-Aldrich

Hypotaurine

≥98% (TLC)

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Synonym(s):
2-Aminoethanesulfinic acid
Empirical Formula (Hill Notation):
C2H7NO2S
CAS Number:
Molecular Weight:
109.15
MDL number:
PubChem Substance ID:
NACRES:
NA.22

Quality Level

Assay

≥98% (TLC)

color

white to off-white

solubility

H2O: 100 mg/mL

SMILES string

NCCS(O)=O

InChI

1S/C2H7NO2S/c3-1-2-6(4)5/h1-3H2,(H,4,5)

InChI key

VVIUBCNYACGLLV-UHFFFAOYSA-N

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1 of 4

This Item
86329703443127442
Hypotaurine ≥98% (TLC)

Sigma-Aldrich

H1384

Hypotaurine

-
Taurine BioUltra, ≥99.5% (T)

Sigma-Aldrich

86329

Taurine

Premium Grade
Taurine-1,1,2,2-d4 99 atom % D, 98% (CP)

Sigma-Aldrich

703443

Taurine-1,1,2,2-d4

-
solubility

H2O: 100 mg/mL

solubility

H2O: 0.5 M at 20 °C, clear, colorless

solubility

-

solubility

-

Quality Level

200

Quality Level

200

Quality Level

200

Quality Level

100

color

white to off-white

color

colorless

color

-

color

-

Application

Hypotaurine has been used as a supplement in fertilization medium (Fert- tyrode albumin lactate pyruvate (TALP)), which used in in-vitro fertilization and evaluation of embryo development. It is also used as a H2S scavenger.

Biochem/physiol Actions

Hypotaurine, a cystamine analog, is the precursor for taurine synthesis. It can act as an antioxidant and singlet oxygen scavenger, thereby protecting cells from oxidative damage. Hypotaurine is reported to play an important role in the maintenance and stimulation of sperm motility and also in vitro fertilization and embryo development.
Antioxidant that binds hydroxyl radicals. Endogenous inhibitory neuromodulator that is blocked by strychnine and picrotoxin. Inhibits the Na2+-dependent transport of GABA and β-alanine. It is a degradation product of cysteine and a precursor of taurine.

Pictograms

Exclamation mark

Signal Word

Warning

Hazard Statements

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

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705578-5MG-PW

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MMYOMAG-74K-13

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Taurine suitable for cell culture, meets USP testing specifications

Sigma-Aldrich

T8691

Taurine

Satoshi Sugimura et al.
Scientific reports, 7(1), 6815-6815 (2017-07-30)
During antral folliculogenesis, developmental competence of prospective oocytes is regulated in large part by the follicular somatic component to prepare the oocyte for the final stage of maturation and subsequent embryo development. The underlying molecular mechanisms are poorly understood. Oocytes
Inhibitors of protein disulfide isomerase suppress apoptosis induced by misfolded proteins.
Hoffstrom BG
Nature Chemical Biology, 6(12), 900-900 (2010)
Improvement of bovine semen quality by removal of membrane-damaged sperm cells with DNA aptamers and magnetic nanoparticles.
Farini V L, et al.
Journal of Biotechnology, 229 , 33-41 (2016)
The antioxidant action of taurine, hypotaurine and their metabolic precursors.
Aruoma OI
The Biochemical Journal, 256(1), 251-251 (1988)
Keiji Mochida et al.
PloS one, 8(1), e49316-e49316 (2013-01-24)
Procedures for cryopreserving embryos vary considerably, each having its specific advantages and disadvantages in terms of technical feasibility, embryo survival yield, temperature permissibility and species- or strain-dependent applicability. Here we report a high osmolality vitrification (HOV) method that is advantageous

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