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T8691

Sigma-Aldrich

Taurine

suitable for cell culture, BioXtra, meets USP testing specifications

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Synonym(s):
2-Aminoethanesulfonic acid
Linear Formula:
NH2CH2CH2SO3H
CAS Number:
Molecular Weight:
125.15
Beilstein/REAXYS Number:
1751215
EC Number:
MDL number:
UNSPSC Code:
12352209
PubChem Substance ID:
NACRES:
NA.26

agency

meets USP testing specifications

Quality Level

product line

BioXtra

form

crystalline powder

technique(s)

cell culture | mammalian: suitable

impurities

endotoxin, tested

color

white

mp

>300 °C (lit.)

SMILES string

NCCS(O)(=O)=O

InChI

1S/C2H7NO3S/c3-1-2-7(4,5)6/h1-3H2,(H,4,5,6)

InChI key

XOAAWQZATWQOTB-UHFFFAOYSA-N

Gene Information

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Application

Taurine has been used:
  • as a component of cardiomyocyte dissociation solution
  • as a supplement for modified synthetic oviduct fluid (m-SOF) medium to culture the presumptive zygotes
  • as a constituent of low Ca2+ solution employed in preparation of collagenase B solution for colony dissociation into single cells
  • to assess its effect on development of bovine embryos fertilized with different bull semen during in vitro fertilization
  • as a component of culture media for derivation of cornea organoids

Biochem/physiol Actions

Non-selective endogenous agonist at glycine receptors. Conditionally essential sulfonated amino acid which modulates apoptosis in some cells; functions in many metabolic activities; a product of methionine and cysteine metabolism.
Taurine is predominantly found in the retina and heart and is also found in the brain, intestine, skeletal muscles and kidneys. It controls the concentration of intracellular calcium, protects against ischemia-reperfusion injury and possesses blood pressure-lowering properties. Taurine also plays a vital role in bile formation and fat digestion. Deficiency of taurine is associated with development of anxiety, hyperactivity, epilepsy and depression.

wgk_germany

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves


Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Patient-specific induced pluripotent stem cell models: generation and characterization of cardiac cells
Zanella F and Sheikh F
Methods in Molecular Biology, 147-162 (2014)
The Effect of Various Concentrations of Taurine during In vitro Fertilization on the Development of Bovine Embryos Fertilized with Spermatozoa from Three Different Bulls
Tsuzuki Y, et al.
Asian-Australasian Journal of Animal Sciences (2010)
Scalable expansion of human pluripotent stem cells in suspension culture
Zweigerdt R, et al.
Nature Protocols, 6(5), 689-689 (2011)
Cornea organoids from human induced pluripotent stem cells
Foster JW, et al.
Scientific Reports, 7 (2017)
The potential health benefits of taurine in cardiovascular disease.
Xu YJ
Experimental and Clinical Cardiology, 13(2), 57-65 (2008)

Articles

Ultrapure water from Milli-Q® system shown free of BPA, suitable for embryology research, minimizing endocrine disruptor interference.

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