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T4571

SAFC

Taurine

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Synonym(s):
2-Aminoethanesulfonic acid
Linear Formula:
NH2CH2CH2SO3H
CAS Number:
Molecular Weight:
125.15
Beilstein/REAXYS Number:
1751215
EC Number:
MDL number:
NACRES:
NA.26

biological source

non-animal source

Quality Level

assay

≥98.5%

form

crystalline powder

manufacturer/tradename

Ajinomoto

technique(s)

cell culture | mammalian: suitable

impurities

endotoxin, heavy metals, trace metals, tested

mp

>300 °C (lit.)

solubility

H2O: ≥100 mg/mL

foreign activity

cytotoxicity, tested

SMILES string

NCCS(O)(=O)=O

InChI

1S/C2H7NO3S/c3-1-2-7(4,5)6/h1-3H2,(H,4,5,6)

InChI key

XOAAWQZATWQOTB-UHFFFAOYSA-N

Gene Information

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T4321T4071G5792
vibrant-m

T4571

Taurine

vibrant-m

T4321

L-Tyrosine

vibrant-m

T4071

L-Threonine

vibrant-m

G5792

L-Glutamine

technique(s)

cell culture | mammalian: suitable

technique(s)

cell culture | mammalian: suitable

technique(s)

cell culture | mammalian: suitable

technique(s)

cell culture | mammalian: suitable

assay

≥98.5%

assay

≥99%

assay

≥98.5%

assay

≥99%

impurities

endotoxin, heavy metals, trace metals, tested

impurities

endotoxin, heavy metals, trace metals, residual solvents, tested

impurities

endotoxin, heavy metals, trace metals, residual solvents, tested

impurities

endotoxin, heavy metals, residual solvents, tested

solubility

H2O: ≥100 mg/mL

solubility

1 M HCl: 25 mg/mL

solubility

H2O: 50 mg/mL

solubility

H2O: 25 mg/mL

Quality Level

400

Quality Level

400

Quality Level

400

Quality Level

400

General description

Our SAFC® portfolio of high-quality raw materials for use in biopharmaceutical processing withstands strict quality control procedures plus the documentation and expertise to help our customers meet requirements as defined by the M-Clarity Program.

M-Clarity Program

Our comprehensive portfolio of upstream process chemicals not only provides biopharmaceutical manufacturers with high-quality raw materials for production of classical and novel therapies, but also helps them get to market faster and simplify regulatory challenges. Trust us to deliver supply chain transparency and reliable sourcing around the globe, streamlining your product qualification with best-in-class regulatory support and service.
To request documentation for this product, please contact Customer Support and select ‘Product Documentation′. Please note that access to documentation for this product requires a confidentiality disclosure agreement.

Application

Taurine is a derivative of the sulfur-containing (sulfhydryl) amino acid cysteine. Taurine is one of the few known naturally occurring sulfonic acids. It is a conditionally essential sulfonated amino acid which modulates apoptosis in some cells; functions in many metabolic activities; a product of methionine and cysteine metabolism. It can be used as a cell culture media component for the commercial biomanufacture of therapeutic recombinant proteins and monoclonal antibodies.

Biochem/physiol Actions

Non-selective endogenous agonist at glycine receptors. Conditionally essential sulfonated amino acid which modulates apoptosis in some cells; functions in many metabolic activities; a product of methionine and cysteine metabolism.

Legal Information

SAFC is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class

11 - Combustible Solids

wgk_germany

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves


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Takashi Ito et al.
Journal of molecular and cellular cardiology, 44(5), 927-937 (2008-04-15)
The sulfur-containing beta-amino acid, taurine, is the most abundant free amino acid in cardiac and skeletal muscle. Although its physiological function has not been established, it is thought to play an important role in ion movement, calcium handling, osmoregulation and
Marlene Wewalka et al.
The Journal of clinical endocrinology and metabolism, 99(4), 1442-1451 (2014-01-18)
Bile acids (BAs) are newly recognized signaling molecules in glucose and energy homeostasis. Differences in BA profiles with type 2 diabetes mellitus (T2D) remain incompletely understood. The objective of the study was to assess serum BA composition in impaired glucose-tolerant
Felizia K Voss et al.
Science (New York, N.Y.), 344(6184), 634-638 (2014-05-03)
Regulation of cell volume is critical for many cellular and organismal functions, yet the molecular identity of a key player, the volume-regulated anion channel VRAC, has remained unknown. A genome-wide small interfering RNA screen in mammalian cells identified LRRC8A as
Tsutomu Suzuki et al.
Wiley interdisciplinary reviews. RNA, 2(3), 376-386 (2011-10-01)
Mitochondrial DNA mutations that cause mitochondrial dysfunction are responsible for a wide spectrum of human diseases, referred to as mitochondrial diseases. Pathogenic point mutations are found frequently in genes encoding mitochondrial (mt) tRNAs, indicating that impaired functioning of mutant mt
M Axelson et al.
Hepatology (Baltimore, Md.), 31(6), 1305-1312 (2000-05-29)
The biosynthesis of bile acids by primary cultures of normal human hepatocytes has been investigated. A general and sensitive method for the isolation and analysis of sterols and bile acids was used, based on anion exchange chromatography and gas chromatography-mass

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