MilliporeSigma

GABRB3

gamma-aminobutyric acid (GABA) A receptor, beta 3

Synonyms:
ECA5
Species:
UniProtKB ID:
Gene ID:
  • Human(2562) Summary: This gene encodes a member of the ligand-gated ionic channel family. The encoded protein is one the subunits of a multi-subunit chloride channel that serves as the receptor for gamma-aminobutyric acid, a major inhibitory neurotransmitter of the mammalian nervous system. This gene is located on the long arm of chromosome 15 in a cluster with two other genes encoding related subunits of the family. This gene may be associated with the pathogenesis of several disorders including Angelman syndrome, Prader-Willi syndrome, nonsyndromic orofacial clefts, epilepsy and autism. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2013]
  • Mouse(14402) gamma-aminobutyric acid (GABA) A receptor, subunit beta 3
  • Rat(24922) gamma-aminobutyric acid (GABA) A receptor, beta 3
  • Zebrafish(566922) gamma-aminobutyric acid (GABA) A receptor, beta 3
  • chicken(396290) gamma-aminobutyric acid (GABA) A receptor, beta 3
  • Horse(100050803) gamma-aminobutyric acid (GABA) A receptor, beta 3
  • cow(529593) gamma-aminobutyric acid (GABA) A receptor, beta 3
  • dog(606913) gamma-aminobutyric acid (GABA) A receptor, beta 3
  • sheep(101114905) gamma-aminobutyric acid (GABA) A receptor, beta 3
  • domestic cat(100286790) gamma-aminobutyric acid (GABA) A receptor, beta 3
  • domestic guinea pig(100731340) gamma-aminobutyric acid (GABA) A receptor, beta 3
  • naked mole-rat(101711687) gamma-aminobutyric acid (GABA) A receptor, beta 3

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Small Molecule - Agonist

Product Number
Description
Species
Gaboxadol hydrochloride, solid, ≥98% (HPLC),
Species
human
Isoguvacine hydrochloride, solid,
Species
human
Muscimol hydrobromide, ≥98% (HPLC), solid,
Species
human
Piperidine-4-sulfonic acid, ,
Species
human
Meprobamate solution, 1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®,
Species
human

Small Molecule - Allosteric Modulator

Product Number
Description
Species
Dehydroisoandrosterone 3-sulfate sodium salt dihydrate, ≥93% (TLC), powder,
Species
human
5α-Pregnan-3α-ol-11,20-dione, powder, ≥98% (TLC),
Species
human
3α,21-Dihydroxy-5α-pregnan-20-one, ≥95%,
Species
human
trans-Dehydroandrosterone, ≥99%,
Species
human, rat
Oxazepam, European Pharmacopoeia (EP) Reference Standard,
Species
human

Small Molecule - Antagonist

Product Number
Description
Species
Picrotoxin, powder,
Species
human
Pregnenolone sulfate sodium salt, ,
Species
human
SR-95531, ≥98% (HPLC), powder,
Species
human
3α,21-Dihydroxy-5α-pregnan-20-one, ≥95%,
Species
human
trans-Dehydroandrosterone, ≥99%,
Species
human, rat

Antibodies

Product Number
Description
Species Reactivity
Application
Anti-GABRB3 antibody produced in goat, affinity isolated antibody, buffered aqueous solution,
Species Reactivity
canine, human, mouse, rat
Application
ELISA
immunohistochemistry
Anti-GABRB3 antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
bovine, dog, guinea pig, horse, human, mouse, rabbit, rat
Application
immunohistochemistry
western blot
Monoclonal Anti-GABRB3 antibody produced in mouse, clone S87-25, 1 mg/mL, purified immunoglobulin,
Species Reactivity
human, mouse, rat
Application
immunocytochemistry
western blot

Small Molecule - Inhibitor

Product Number
Description
Species
NO-711 hydrochloride, ≥98% (HPLC),
Species
human
(±)-Vigabatrin, ,
Species
human
2,6-Diisopropylphenol, 97%,
Species
human
Topiramate solution, 1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®,
Species
human
Topiramate, European Pharmacopoeia (EP) Reference Standard,
Species
human

Small Molecule - Ligand

Product Number
Description
Species
Etomidate, >98% (HPLC), powder,
Species
human
Flumazenil, >99% (HPLC), solid,
Species
rat, human
Carbamazepine, powder,
Species
rat, human
2-Bromo-2-chloro-1,1,1-trifluoroethane, ≥99%,
Species
human

esiRNA

Product Number
Description
Species
MISSION® esiRNA, targeting human GABRB3,
Species
human