MilliporeSigma

STAT3

signal transducer and activator of transcription 3 (acute-phase response factor)

Synonyms:
APRF, HIES
Species:
UniProtKB ID:
Gene ID:
  • Human(6774) Summary: The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated through phosphorylation in response to various cytokines and growth factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. This protein mediates the expression of a variety of genes in response to cell stimuli, and thus plays a key role in many cellular processes such as cell growth and apoptosis. The small GTPase Rac1 has been shown to bind and regulate the activity of this protein. PIAS3 protein is a specific inhibitor of this protein. Three alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008]
  • Mouse(20848) signal transducer and activator of transcription 3
  • Rat(25125) signal transducer and activator of transcription 3 (acute-phase response factor)
  • naked mole-rat(101721899) signal transducer and activator of transcription 3 (acute-phase response factor)
  • domestic guinea pig(100717084) signal transducer and activator of transcription 3 (acute-phase response factor)
  • chicken(420027) signal transducer and activator of transcription 3 (acute-phase response factor)
  • Zebrafish(30767) signal transduction and activation of transcription 3
  • sheep(100294659) signal transducer and activator of transcription 3 (acute-phase response factor)
  • domestic cat(101095698) signal transducer and activator of transcription 3 (acute-phase response factor)
  • cow(508541) signal transducer and activator of transcription 3 (acute-phase response factor)
  • Horse(100052852) signal transducer and activator of transcription 3 (acute-phase response factor)
  • Domestic Rabbit(100348778) signal transducer and activator of transcription 3 (acute-phase response factor)
  • dog(490967) signal transducer and activator of transcription 3 (acute-phase response factor)

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ELISA

Product Number
Description
Species
Phosphotyrosine STAT3 / Signal Transducer and Activator of Transcription 3 ELISA Kit, ,
Species
human
Cell-Based ELISA for detecting phospho-STAT3 (pTyr705) in cultured cell lines, 96 assays,
Species
mouse, rat, human
Phospho-Stat3 (pTyr705) and pan-Stat3 ELISA Kit, for detection of phospho-stat3 (pTyr705) and pan-stat3 in human, mouse or rat cell and tissue lysates,
Species
mouse, rat, human
Phospho-Stat3 (pTyr705) ELISA Kit, for detection of phospho-stat3 (pTyr705) in human, mouse or rat cell and tissue lysates,
Species
mouse, rat, human

Antibodies

Product Number
Description
Species Reactivity
Application
Anti-phospho-STAT3 (pTyr705) antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human, mouse, rat
Application
immunohistochemistry
western blot
Anti-STAT3 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Species Reactivity
human
Application
immunohistochemistry
western blot
Rabbit anti-STAT3 Antibody, Affinity Purified, Powered by Bethyl Laboratories, Inc.,
Species Reactivity
human
Application
immunoprecipitation (IP)
Anti-STAT3 antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
bovine, dog, horse, human, mouse, pig, rabbit, rat
Application
immunohistochemistry
western blot
Anti-STAT3 antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
bovine, dog, guinea pig, horse, human, mouse, rabbit, rat, sheep
Application
immunohistochemistry
western blot

Cell Lines

Product Number
Description
Species
SKOV3 Cells GFP-STAT3, ,
Species
human
A549 Cells RFP-STAT3, ,
Species
human

esiRNA

Product Number
Description
Species
MISSION® esiRNA, targeting mouse Stat3,
Species
mouse
MISSION® esiRNA, targeting human STAT3,
Species
human