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1.01728

Sigma-Aldrich

OSTEOSOFT®

mild decalcifier-solution for histology

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About This Item

UNSPSC Code:
12352401
NACRES:
NA.21

Quality Level

400

form

liquid

IVD

for in vitro diagnostic use

color

dark red

pH

7.0-7.3 (20 °C in H2O)

density

1.10 g/mL at 20 °C

application(s)

diagnostic assay manufacturing
hematology
histology

storage temp.

15-25°C

Related Categories

General description

This ready-to-use product, OSTEOSOFT® - mild decalcifier-solution for histology, has been specifically developed for human cell diagnostics in humans and is used for the demineralization and decalcification of bones, punched bone-marrow specimens, and other hard tissue of human origin.
Decalcification is necessary for optical microscopic examinations of hard tissue in routine histological procedures. For the decalcification of sensitive, calcium-containing tissues, such as iliac crest biopsies, OSTEOSOFT® can be used. Its formulation is based on EDTA. Its pendant, OSTEOMOLL®(Product number 1.01736), can be used for the decalcification of hard tissue such as teeth and bone as its formulation is based on formaldehyde and acetic acid. The amount of OSTEOSOFT®needed is dependent upon on the size, type and thickness of the material. Both solutions are color-coded, to distinguish them from each other, fixatives and solvents used in the histological laboratory. OSTEOSOFT® is color-coded yellow, OSTEOMOLL® is color-coded blue. Whereby OSTEOSOFT® preserves the antigen structures in the tissue, thus, an IHC analysis can be performed, OSTEOMOLL® will be used for tissues that are not destined for antibody analysis.
Both decalcifiers can be used for clinical diagnostic purposes and in laboratory accreditation processes as they are certified and registered as IVD and CE product. OSTEOSOFT® is used only once and fresh solution must be used for each tissue. The quantity of OSTEOSOFT® required is dependent on the size, type, and density of the respective material. For more details, please see instructions for use (IFU). The IFU can be downloaded from this webpage.

Legal Information

OSTEOMOLL is a registered trademark of Merck KGaA, Darmstadt, Germany
OSTEOSOFT is a registered trademark of Merck KGaA, Darmstadt, Germany

pictograms

Health hazardCorrosion
GHS08,GHS05

signalword

Danger

hcodes

H318,H373

Hazard Classifications

Eye Dam. 1 - STOT RE 2 Inhalation

target_organs

Respiratory Tract

Storage Class

12 - Non Combustible Liquids

wgk_germany

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Ivana Kurelac et al.
Journal of clinical medicine, 8(12) (2019-12-15)
A cogent issue in cancer research is how to account for the effects of tumor microenvironment (TME) on the response to therapy, warranting the need to adopt adequate in vitro and in vivo models. This is particularly relevant in the

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