MilliporeSigma

1.06187

SAFC

Meglumine

EMPROVE® EXPERT, Ph. Eur., ChP, JP, USP

Synonym(s):
N-Methyl-D-glucamine, 1-Deoxy-1-methylaminosorbitol, 1-Deoxy-1-methylaminosorbitol, 1-Deoxy-1-(methylamino)-D-glucitol, Meglumine
Empirical Formula (Hill Notation):
C7H17NO5
CAS Number:
Molecular Weight:
195.21
Beilstein:
385906
MDL number:
EC Index Number:
228-506-9

Agency

ChP
JP
Ph. Eur.
USP

Quality Level

product line

EMPROVE® EXPERT

form

solid

autoignition temp.

~662 °F

pH

11 (20 °C, 10 g/L in H2O)

bp

210 °C/1013 hPa

mp

129-131.5 °C (lit.)

application(s)

liquid formulation
pharmaceutical
solid formulation
solubility enhancement

storage temp.

no temp limit

SMILES string

CNC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO

InChI

1S/C7H17NO5/c1-8-2-4(10)6(12)7(13)5(11)3-9/h4-13H,2-3H2,1H3/t4-,5+,6+,7+/m0/s1

InChI key

MBBZMMPHUWSWHV-BDVNFPICSA-N

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1 of 4

This Item
PHR1324137914066930
Meglumine EMPROVE® EXPERT, Ph. Eur., ChP, JP, USP

SAFC

1.06187

Meglumine

Meglumine Pharmaceutical Secondary Standard; Certified Reference Material

Supelco

PHR1324

Meglumine

Meglumine United States Pharmacopeia (USP) Reference Standard

USP

1379140

Meglumine

N-Methyl-D-glucamine ReagentPlus®, ≥99.0% (T)

Sigma-Aldrich

66930

N-Methyl-D-glucamine

form

solid

form

-

form

-

form

powder

mp

129-131.5 °C (lit.)

mp

129-131.5 °C (lit.)

mp

129-131.5 °C (lit.)

mp

126-131 °C, 129-131.5 °C (lit.)

storage temp.

no temp limit

storage temp.

2-30°C

storage temp.

-

storage temp.

-

Quality Level

500

Quality Level

300

Quality Level

-

Quality Level

200

agency

ChP

agency

traceable to Ph. Eur. Y0001209, traceable to USP 1379140

agency

-

agency

-

General description

When working on a pharmaceutical formulation, there are specific considerations to make and challenging hurdles to take before you can successfully launch your final drug product - formulation stability, release kinetics and bioavailability limitations just to name a few. With our application know-how and regulatory expertise, we support you in every step of development, scale-up, and production.
As part of our Emprove® Program, our raw materials are offered with extensive documentation facilitating compliance of your pharma and biopharma product, full supply chain transparency and risk mitigation. Our SAFC® portfolio of high-quality products for biopharmaceutical and pharmaceutical formulation and production withstands strict quality control procedures and is produced according to applicable cGMP guidelines.

Application

Meglumine Emprove® Essential is a robust pharmaceutical excipient that can provide stability, solubility enhancement and pH modification in solid and liquid formulations.

Legal Information

Emprove is a registered trademark of Merck KGaA, Darmstadt, Germany
SAFC is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class Code

11 - Combustible Solids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


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Articles

API Solubility and Dissolution Enhancement Via Formulation

Our overview of API solubility and dissolution enhancement methods can help you decide between the many options to take during formulation.

Overcoming Excipient Risks and Challenges for Parenteral Formulations

This overview describes the challenges when developing parenteral formulations and strategies to overcome them and reduce the risk of production.

Active Pharmaceutical Ingredient (API) Stability in Solid Dose Formulation

This article describes the use of excipients to help address API stability issues.

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