MilliporeSigma
All Photos(1)

Documents

8.22278

Sigma-Aldrich

Acetic anhydride

for synthesis

Sign Into View Organizational & Contract Pricing

Synonym(s):
Acetic anhydride, Acetyl acetate, Acetyl oxide
Linear Formula:
(CH3CO)2O
CAS Number:
Molecular Weight:
102.09
MDL number:
EC Index Number:
203-564-8

vapor pressure

4 hPa ( 20 °C)

Quality Level

Assay

≥98.0% (GC)

form

liquid

autoignition temp.

330 °C

potency

630 mg/kg LD50, oral (Rat)
4320 mg/kg LD50, skin (Rabbit)

expl. lim.

2.0-10.2 % (v/v)

pH

3 (20 °C, 10 g/L in H2O)

mp

-73 °C

transition temp

flash point 49 °C

density

1.08 g/cm3 at 20 °C

storage temp.

2-30°C

InChI

1S/C4H6O3/c1-3(5)7-4(2)6/h1-2H3

InChI key

WFDIJRYMOXRFFG-UHFFFAOYSA-N

Compare Similar Items

View Full Comparison

Show Differences

1 of 4

This Item
33214320102242845
Acetic anhydride for synthesis

Sigma-Aldrich

8.22278

Acetic anhydride

Acetic anhydride puriss. p.a., ACS reagent, reag. ISO, reag. Ph. Eur., ≥99% (GC)

Sigma-Aldrich

33214

Acetic anhydride

Acetic anhydride ReagentPlus®, ≥99%

Sigma-Aldrich

320102

Acetic anhydride

Acetic anhydride ACS reagent, ≥98.0%

Sigma-Aldrich

242845

Acetic anhydride

assay

≥98.0% (GC)

assay

≥99% (GC)

assay

≥99%

assay

≥98.0%

form

liquid

form

-

form

liquid

form

liquid

pH

3 (20 °C, 10 g/L in H2O)

pH

-

pH

-

pH

-

mp

-73 °C

mp

−73 °C (lit.)

mp

−73 °C (lit.)

mp

−73 °C (lit.)

density

1.08 g/cm3 at 20 °C

density

1.08 g/mL (lit.)

density

1.08 g/mL (lit.)

density

1.08 g/mL (lit.)

General description

Acetic anhydride is a widely used reagent in organic synthesis. The reagent is effective for acetylating alcohols, amines, and thiols. Additionally, it is used in various named reactions such as the Pummerer reaction, the Perkin reaction, the Polonovski reaction, the N-oxide reaction, and the Thiele reaction. Acetic anhydride is an effective reagent during oxidation of alcohols, dehydration, ether cleavage, enol acetate formation, and gem-diacetate formation.

Application

Acetic anhydride is used:
  • In the solvent free acylation of 2-methylfuran to 2-acetyl-5-methylfuran in presence of hydroxide fluorides catalyst.
  • As a catalyst in the synthesis of 3-arylideneisobenzofuran-1(3H)-one derivatives from phthalic anhydride and quinoline derivatives.
  • In the preparation of hyperbranched poly ethoxy siloxanes by condensation reaction with tetra ethoxy silane in presence of an organotitanium catalyst.

Analysis Note

Assay (GC, area%): ≥ 98.0 % (a/a)
Density (d 20 °C/ 4 °C): 1.080 - 1.082
Identity (IR): passes test

Signal Word

Danger

Hazard Statements

Hazard Classifications

Acute Tox. 2 Inhalation - Acute Tox. 4 Oral - Eye Dam. 1 - Flam. Liq. 3 - Skin Corr. 1B

Storage Class Code

3 - Flammable liquids

WGK

WGK 1

Flash Point(F)

120.2 °F - closed cup

Flash Point(C)

49 °C - closed cup


Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Documents related to the products that you have purchased in the past have been gathered in the Document Library for your convenience.

Visit the Document Library

Difficulty Finding Your Product Or Lot/Batch Number?

Product numbers are combined with Pack Sizes/Quantity when displayed on the website (example: T1503-25G). Please make sure you enter ONLY the product number in the Product Number field (example: T1503).

Example:

T1503
Product Number
-
25G
Pack Size/Quantity

Additional examples:

705578-5MG-PW

PL860-CGA/SHF-1EA

MMYOMAG-74K-13

1000309185

enter as 1.000309185)

Having trouble? Feel free to contact Technical Service for assistance.

Lot and Batch Numbers can be found on a product's label following the words 'Lot' or 'Batch'.

Aldrich Products

  • For a lot number such as TO09019TO, enter it as 09019TO (without the first two letters 'TO').

  • For a lot number with a filling-code such as 05427ES-021, enter it as 05427ES (without the filling-code '-021').

  • For a lot number with a filling-code such as STBB0728K9, enter it as STBB0728 without the filling-code 'K9'.

Not Finding What You Are Looking For?

In some cases, a COA may not be available online. If your search was unable to find the COA you can request one.

Request COA

Customers Also Viewed

Slide 1 of 6

1 of 6

4-Aminophenol for synthesis

Sigma-Aldrich

8.00421

4-Aminophenol

Calcium hypochlorite for synthesis

Sigma-Aldrich

8.41799

Calcium hypochlorite

Acetylsalicylic acid analytical standard

Sigma-Aldrich

A3160

Acetylsalicylic acid

Phenylacetic acid for synthesis

Sigma-Aldrich

8.20993

Phenylacetic acid

Acetyl chloride for synthesis

Sigma-Aldrich

8.22252

Acetyl chloride

Inorganic hydroxide fluorides as solid catalysts for acylation of 2-methylfuran by acetic anhydride
Frouri F, et al.
Applied Catalysis. B, Environmental, 168, 515-523 (2015)
Acetic Anhydride
Regina Zibuck
Encyclopedia of Reagents for Organic Synthesis, Second Edition (2001)
One-pot synthesis of hyperbranched polyethoxysiloxanes
Zhu X, et al.
Macromolecules, 39(5), 1701-1708 (2016)

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service