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A3648

Sigma-Aldrich

(3-Aminopropyl)triethoxysilane

≥98%

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Synonym(s):
APTS, 3-Triethoxysilylpropylamine, APTES
Linear Formula:
H2N(CH2)3Si(OC2H5)3
CAS Number:
Molecular Weight:
221.37
Beilstein:
1754988
EC Number:
MDL number:
PubChem Substance ID:
NACRES:
NA.47

Quality Level

Assay

≥98%

form

liquid

pH

11 (20 °C, 20 g/L)

bp

217 °C/760 mmHg (lit.)

mp

220-222 °C

density

0.946 g/mL at 25 °C (lit.)

application(s)

diagnostic assay manufacturing
hematology
histology

storage temp.

room temp

SMILES string

CCO[Si](CCCN)(OCC)OCC

InChI

1S/C9H23NO3Si/c1-4-11-14(12-5-2,13-6-3)9-7-8-10/h4-10H2,1-3H3

InChI key

WYTZZXDRDKSJID-UHFFFAOYSA-N

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This Item
44014074144250059
form

liquid

form

liquid

form

liquid

form

-

bp

217 °C/760 mmHg (lit.)

bp

217 °C/760 mmHg (lit.)

bp

217 °C/760 mmHg (lit.)

bp

-

mp

220-222 °C

mp

-

mp

-

mp

-

density

0.946 g/mL at 25 °C (lit.)

density

0.946 g/mL at 25 °C (lit.)

density

0.929 g/mL at 25 °C, 0.946 g/mL at 25 °C (lit.)

density

1.004 g/mL at 20 °C (lit.)

storage temp.

room temp

storage temp.

-

storage temp.

-

storage temp.

-

Application

  • (3-Aminopropyl)triethoxysilane has been used for the preparation of cadherin surfaces on glass slides.
  • It has been used for the preparation of RGD (Arg-Gly-Asp)-treated silicone membranes.
  • It has been used for the preparation of the avidin–biotin coverslips.

Biochem/physiol Actions

(3-Aminopropyl)triethoxysilane forms aminopropyl derivative of glass, an adsorbent for affinity chromatography. It is used to prepare positively charged slides suitable for use with various immunohistochemical and in situ hybridization procedures.

Pictograms

CorrosionExclamation mark

Signal Word

Danger

Hazard Statements

Hazard Classifications

Acute Tox. 4 Oral - Eye Dam. 1 - Skin Corr. 1B - Skin Sens. 1

Storage Class Code

8A - Combustible, corrosive hazardous materials

WGK

WGK 1

Flash Point(F)

199.4 °F - closed cup

Flash Point(C)

93 °C - closed cup

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Real-time observation of a single DNA digestion by lambda exonuclease under a fluorescence microscope field.
Matsuura S, et al.
Nucleic Acids Research, 29, E79-E79 (2001)
Apoptosis and survival of osteoblast-like cells are regulated by surface attachment.
Grigoriou V, et al.
The Journal of Biological Chemistry, 280, 1733-1739 (2005)
Peng Yuan et al.
Nanotechnology, 23(37), 375705-375705 (2012-08-28)
The surfaces of naturally occurring halloysite nanotubes were functionalized with γ-aminopropyltriethoxysilane (APTES), which was found to have a substantial effect on the loading and subsequent release of a model dye molecule. APTES was mostly anchored at the internal lumen surface
Isabelle Bonnet et al.
Nucleic acids research, 36(12), 4118-4127 (2008-06-12)
The restriction endonuclease EcoRV can rapidly locate a short recognition site within long non-cognate DNA using 'facilitated diffusion'. This process has long been attributed to a sliding mechanism, in which the enzyme first binds to the DNA via nonspecific interaction
Sri Ram Krishna Vedula et al.
Nature communications, 6, 6111-6111 (2015-01-23)
The closure of gaps within epithelia is crucial to maintain its integrity during biological processes such as wound healing and gastrulation. Depending on the distribution of extracellular matrix, gap closure occurs through assembly of multicellular actin-based contractile cables or protrusive

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