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87809

Sigma-Aldrich

Retinyl propionate

≥98.0% (sum of isomers, HPLC), ~2500 U/mg

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Synonym(s):
Vitamin A propionate
Empirical Formula (Hill Notation):
C23H34O2
CAS Number:
Molecular Weight:
342.51
Beilstein/REAXYS Number:
2475675
EC Number:
MDL number:
eCl@ss:
34058020
PubChem Substance ID:
NACRES:
NA.79

biological source

synthetic

Quality Level

assay

≥98.0% (sum of isomers, HPLC)

form

liquid

specific activity

~2500 U/mg

contains

BHT as stabilizer

impurities

~5% cis-isomers

color

green-yellow to very dark green-yellow
yellow to very dark yellow

storage temp.

2-8°C

SMILES string

CCC(=O)OC\C=C(C)\C=C\C=C(C)\C=C\C1=C(C)CCCC1(C)C

InChI

1S/C23H34O2/c1-7-22(24)25-17-15-19(3)11-8-10-18(2)13-14-21-20(4)12-9-16-23(21,5)6/h8,10-11,13-15H,7,9,12,16-17H2,1-6H3/b11-8+,14-13+,18-10+,19-15+

InChI key

SFRPDSKECHTFQA-ONOWFSFQSA-N

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1 of 4

This Item
R325095144R4632
vibrant-m

87809

Retinyl propionate

-
vibrant-m

R3250

Retinyl acetate

-
vibrant-m

95144

Retinol

Premium Grade
vibrant-m

R4632

Retinyl acetate

-
biological source

synthetic

biological source

synthetic

biological source

synthetic

biological source

synthetic

storage temp.

2-8°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

Quality Level

100

Quality Level

200

Quality Level

200

Quality Level

300

form

liquid

form

matrix dispersion

form

(Powder or Powder with Lumps)

form

crystalline solid or supercooled liquid

color

green-yellow to very dark green-yellow

color

yellow

color

faint yellow to very dark yellow

color

light yellow to dark yellow

General description

Retinal, retinol and retinoic acid are the aldehyde, alcohol and acid forms of vitamin A. The retinoids exist as many geometric isomers due to the unsaturated bonds in the aliphatic chain. Retinoids also exist as retinyl esters such as retinyl propionate, retinyl acetate and retinyl palmitate.

Application

Retinyl propionate has been used to determine its effects on performance, egg quality, serum and egg oxidative status and vitamin A levels in laying quails.

Biochem/physiol Actions

Retinyl esters provide pools of vitamin A that are converted into retinol and other retinoids as needed. Retinyl propionate is used in various formulations to control wrinkles.

Unit Definition

1 international unit according to PH EUR II, 217 (1983)

pictograms

Health hazard

signalword

Danger

Hazard Classifications

Aquatic Chronic 4 - Repr. 1B

Storage Class

6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk_germany

WGK 2

flash_point_f

262.4 °F - closed cup

flash_point_c

128 °C - closed cup

ppe

Eyeshields, Gloves, type ABEK (EN14387) respirator filter


Certificates of Analysis (COA)

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9-cis-Retinal vitamin A analog

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9-cis-Retinal

Retinyl acetate United States Pharmacopeia (USP) Reference Standard, solution of retinyl acetate (vitamin A) in peanut oil

USP

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R0300000

Retinol acetate

Retinol solution 100 μg/mL ± 25% (Refer to COA) (Ethanol with 0.1% (w/v) BHT), ampule of 1 mL, reference material, Cerilliant®

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9-cis-Retinoic acid ≥98% (HPLC)

Sigma-Aldrich

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S Donoghue et al.
The Journal of nutrition, 115(12), 1562-1571 (1985-12-01)
Twelve ewes were fed retinyl propionate equivalent to 12,000 micrograms retinol/kg body weight per day for the last two trimesters of pregnancy (group fed high vitamin A). Four ewes received a control level of 120 micrograms/kg body weight per day.
C Green et al.
Clinical and experimental dermatology, 23(4), 162-167 (1999-01-23)
The clinical and histological effects of retinyl propionate cream (a retinyl ester) on extrinsic skin ageing (photo-ageing) in man were assessed in a double-blind randomized placebo-controlled study of 80 subjects, individual parameters of this being assessed for each treatment site
Joseph R Kaczvinsky et al.
Journal of cosmetic dermatology, 8(3), 228-233 (2009-09-09)
The periorbital area is a key wrinkle-prone region, where the first signs of aging usually appear. To demonstrate the ability of new anti-aging moisturizing products to improve overall smoothness and wrinkle depth appearance in the periorbital region via the Fast
J J J Fu et al.
The British journal of dermatology, 162(3), 647-654 (2010-04-09)
Tretinoin is considered the benchmark prescription topical therapy for improving fine facial wrinkles, but skin tolerance issues can affect patient compliance. In contrast, cosmetic antiwrinkle products are well tolerated but are generally presumed to be less efficacious than tretinoin. To
Effect of retinol and retinol esters on performance, egg quality, and blood and egg vitamin A levels in laying quails
Ilhan M and BULBUL T
Turkish Journal of Veterinary and Animal Sciences, 40(5), 590-597 (2016)

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