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A9477

Sigma-Aldrich

Aldosterone

≥95% (HPLC)

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Synonym(s):
11β,21-Dihydroxy-3,20-dioxo-4-pregnen-18-al, 11β,21-Dihydroxypregn-4-ene-3,18,20-trione, 18-Aldocorticosterone, Reichstein X
Empirical Formula (Hill Notation):
C21H28O5
CAS Number:
Molecular Weight:
360.44
Beilstein:
3224996
EC Number:
MDL number:
PubChem Substance ID:
NACRES:
NA.77

biological source

synthetic (organic)

Quality Level

sterility

non-sterile

Assay

≥95% (HPLC)

form

powder

technique(s)

cell culture | mammalian: suitable

solubility

chloroform: 20 mg/mL, clear to slightly hazy, colorless to light yellow

shipped in

ambient

storage temp.

room temp

SMILES string

C[C@]12CCC(=O)C=C1CC[C@H]3[C@@H]4CC[C@H](C(=O)CO)[C@]4(C[C@H](O)[C@H]23)C=O

InChI

1S/C21H28O5/c1-20-7-6-13(24)8-12(20)2-3-14-15-4-5-16(18(26)10-22)21(15,11-23)9-17(25)19(14)20/h8,11,14-17,19,22,25H,2-7,9-10H2,1H3/t14-,15-,16+,17-,19+,20-,21+/m0/s1

InChI key

PQSUYGKTWSAVDQ-ZVIOFETBSA-N

Gene Information

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This Item
C2505C2755H5752
Aldosterone ≥95% (HPLC)

Sigma-Aldrich

A9477

Aldosterone

Corticosterone ≥92%

Sigma-Aldrich

C2505

Corticosterone

Cortisone ≥95%

Sigma-Aldrich

C2755

Cortisone

form

powder

form

powder

form

powder

form

powder

technique(s)

cell culture | mammalian: suitable

technique(s)

-

technique(s)

inhibition assay: suitable

technique(s)

-

solubility

chloroform: 20 mg/mL, clear to slightly hazy, colorless to light yellow

solubility

chloroform: 50 mg/mL, clear, colorless to faintly yellow

solubility

chloroform: methanol (1:1): 50 mg/mL, clear to very slightly hazy, colorless to faintly yellow

solubility

chloroform: 50 mg/mL, clear, colorless to light yellow

shipped in

ambient

shipped in

ambient

shipped in

ambient

shipped in

ambient

storage temp.

room temp

storage temp.

room temp

storage temp.

room temp

storage temp.

room temp

Application

Aldosterone has been used:
  • as a RPMI-1640 medium supplement for podocyte culture to test its pathogenicity in obesity-related glomerulopathy (ORG)
  • in combination with salt to induce renal injury in mice
  • to stimulate primary liver sinusoidal endothelial cells (LSECs) and in the generation of hyperaldosteronism model in mice

The d-isomer of aldosterone is considered to be the biologically active isomer.

Biochem/physiol Actions

Aldosterone is a biologically active aldosterone isomer; a mineralocorticoid produced by the adrenal cortex. It induces urinary excretion of K+ and renal reabsorption of Na+. It is produced from adrenocorticotropic hormone (ACTH) and is essential for maintaining sodium homeostasis in the distal tubules. Aldosterone binds to the mineralocorticoid receptor and may modulate vascular system and induce kidney damage. It contributes to the progression of chronic kidney disease(CKD). Aldosterone is part of the renin-angiotensin-aldosterone system (RAAS).

Other Notes

Exists as an equilibrium mixture of the aldehyde and the hemiacetal.

related product

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Spironolactone European Pharmacopoeia (EP) Reference Standard

S1200000

Spironolactone

Corticosterone ≥92%

Sigma-Aldrich

C2505

Corticosterone

Deoxycorticosterone acetate United States Pharmacopeia (USP) Reference Standard

USP

1174001

Deoxycorticosterone acetate

Aldosterone and Mineralocorticoid Receptor System in Cardiovascular Physiology and Pathophysiology
Cannavo A, et al.
Oxidative Medicine and Cellular Longevity, 2018 (2018)
Role of bardoxolone methyl, a nuclear factor erythroid 2-related factor 2 activator, in aldosterone-and salt-induced renal injury
Hisamichi M
Hypertension Research, 41(1), 8-8 (2018)
Caveolin 1-related autophagy initiated by aldosterone-induced oxidation promotes liver sinusoidal endothelial cells defenestration
Luo X, et al.
Redox Biology, 13(5), 508-521 (2017)
Aldosterone and renin measurements
Cartledge S and Lawson N
Annals of Clinical Biochemistry, 37(3), 262-278 (2000)
Seong-Mi Park et al.
Journal of clinical medicine, 8(7) (2019-07-20)
Although aldosterone has been demonstrated to induce left ventricular (LV) hypertrophy not only in primary aldosteronism but also in primary hypertension (HT), it can be affected by multiple factors, including age, and the effect of aldosterone on LV function is

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