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B9934

Sigma-Aldrich

BTA-1

≥98% (HPLC), solid

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Synonym(s):
2-(4´-Methylaminophenyl)benzothiazole
Empirical Formula (Hill Notation):
C14H12N2S
CAS Number:
Molecular Weight:
240.32
MDL number:
PubChem Substance ID:
NACRES:
NA.77

assay

≥98% (HPLC)

form

solid

color

yellow

solubility

DMSO: soluble ~10 mg/mL

storage temp.

2-8°C

SMILES string

CNc1ccc(cc1)-c2nc3ccccc3s2

InChI

1S/C14H12N2S/c1-15-11-8-6-10(7-9-11)14-16-12-4-2-3-5-13(12)17-14/h2-9,15H,1H3

InChI key

FHJRKGXJBXPBGA-UHFFFAOYSA-N

Gene Information

human ... APP(351)

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1 of 4

This Item
F3680A7232G5547
vibrant-m

B9934

BTA-1

vibrant-m

F3680

10058-F4

vibrant-m

A7232

AP-18

vibrant-m

G5547

GSK837149A

form

solid

form

solid

form

solid

form

solid

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

color

yellow

color

yellow

color

white to off-white

color

white to off-white

solubility

DMSO: soluble ~10 mg/mL

solubility

DMSO: >10 mg/mL, H2O: <2 mg/mL

solubility

DMSO: >10 mg/mL

solubility

DMSO: >10 mg/mL, H2O: insoluble

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

Biochem/physiol Actions

BTA-1 is a probe for β-amyloid aggregates; fluorescent thioflavin-T derivative; exhibits high affinity for amyloid deposits; displays 50-fold higher affinity than thioflavin-T; selectively stains cerebral plaques and cerebrovascular amyloid deposits in the brains of PS1/APP transgenic mice, as well as Aβ fibrils in postmortem brain tissue obtained from AD patients; crosses the blood brain barrier.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)


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Elena Rodriguez-Vieitez et al.
European journal of nuclear medicine and molecular imaging, 42(7), 1119-1132 (2015-04-22)
Pathological studies suggest that neuroinflammation is exacerbated by increased beta-amyloid (Aβ) levels in the brain early in Alzheimer's disease (AD). The time course and relationships between astrocytosis and Aβ deposition were examined using multitracer in vivo positron emission tomography (PET)
Sajjad Molavipordanjani et al.
European journal of medicinal chemistry, 175, 149-161 (2019-05-13)
Six novel 2-arylimidazo[2,1-b]benzothiazole (IBT) derivatives were synthesized as potential tridentate radiotracers for AD imaging purposes. Two of these ligands (6a,b) were successfully labeled with 99mTc radionuclide at high radiochemical purity using fac-[99mTc(CO)3(H2O)3]+ synthon. [99mTc]7a and [99mTc]7b were evaluated as single
William E Klunk et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 23(6), 2086-2092 (2003-03-27)
2-(4'-methylaminophenyl)benzothiazole (BTA-1) is an uncharged derivative of thioflavin-T that has high affinity for Abeta fibrils and shows very good brain entry and clearance. In this study, we asked whether BTA-1, at concentrations typical of those achieved during positron emission tomography
Ruiqing Ni et al.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 59(6), 960-966 (2018-02-09)
Fibrillary tau aggregates in Alzheimer disease and allied neurodegenerative disorders have been visualized in vivo by PET, whereas mechanistic links between PET-detectable tau deposits and neurotoxicity remain elusive. Here, we took advantage of transgenic mouse models of tauopathies to evaluate
Chester A Mathis et al.
Bioorganic & medicinal chemistry letters, 12(3), 295-298 (2002-01-30)
The synthesis of a new lipophilic thioflavin-T analogue (2-[4' -(methylamino)phenyl]benzothiazole, 6) with high affinity for amyloid is reported. Intravenous injection of [(11)C]-labeled 6 in control mice resulted in high brain uptake. Amyloid deposits were imaged with multiphoton microscopy in the

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