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C7752

Sigma-Aldrich

Cytochrome c from equine heart

≥95% based on Mol. Wt. 12,384 basis

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Synonym(s):
Cytochrome c from horse heart
CAS Number:
EC Number:
MDL number:
NACRES:
NA.61

biological source

horse heart

Quality Level

assay

≥95% (SDS-PAGE)
≥95% based on Mol. Wt. 12,384 basis

form

powder

mol wt

12,384

technique(s)

cell culture | mammalian: suitable

suitability

suitable for molecular biology

UniProt accession no.

storage temp.

−20°C

Gene Information

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This Item
C3131C4011C2436
Cytochrome c from equine heart ≥95% based on Mol. Wt. 12,384 basis

C7752

Cytochrome c from equine heart

Cytochrome c from bovine heart ≥95% based on Mol. Wt. 12,327 basis, powder, suitable for mammalian cell culture

C3131

Cytochrome c from bovine heart

technique(s)

cell culture | mammalian: suitable

technique(s)

cell culture | mammalian: suitable

technique(s)

cell culture | mammalian: suitable

technique(s)

-

assay

≥95% (SDS-PAGE), ≥95% based on Mol. Wt. 12,384 basis

assay

≥95% based on Mol. Wt. 12,327 basis

assay

≥95% based on Mol. Wt. 12,173 basis

assay

≥85% based on Mol. Wt. 12,588 basis

mol wt

12,384

mol wt

12327 Da

mol wt

-

mol wt

-

form

powder

form

powder

form

powder

form

powder

suitability

suitable for molecular biology

suitability

-

suitability

-

suitability

-

Application

Cytochrome c is used as an inducer of mitochondria-dependent apoptosis in various research studies. The identification and monitoring of oxidation sites in cytochrome c may have implications for assessing oxidative stress-related conditions and diseases. It could potentially be used as a biomarker to evaluate the extent of oxidative damage and the antioxidant capacity of cells and tissues.

Cytochrome c is suitable for use as a component of phosphate buffer for the detection and evaluation of complex IV activity using blue-native gel electrophoresis (BN-PAGE). It may also be used for the detection of extracellular superoxide anion (ECSA) in isolated kidney phagocytes.
The specific sites and extent of oxidation in horse cytochrome c treated with H2O2 and UV were characterized. It was suggested that the state of these sites could be used as a biomarker for the oxidative environment in a cell.

Biochem/physiol Actions

Cytochrome c has been identified as an important mediator in apoptotic pathways. The release of mitochondrial cytochrome c into the cytoplasm stimulates apoptosis and is commonly used as an indicator of the apoptotic process in the cell.
Cytochrome c is primarily known as an electron-carrying mitochondrial protein. The transition of cytochrome c between the ferrous and ferric states within the cell makes it an efficient biological electron-transporter and it plays a vital role in cellular oxidations in both plants and animals. It is generally regarded as a universal catalyst of respiration, forming an essential electron-bridge between the respirable substrates and oxygen

Preparation Note

Prepared with acetic acid without using TCA.

Other Notes

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)


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