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D0540

Sigma-Aldrich

DNQX

≥98% (TLC)

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Synonym(s):
6,7-Dinitroquinoxaline-2,3(1H,4H)-dione
Empirical Formula (Hill Notation):
C8H4N4O6
CAS Number:
Molecular Weight:
252.14
MDL number:
PubChem Substance ID:
NACRES:
NA.77

Quality Level

assay

≥98% (TLC)

form

powder

SMILES string

[O-][N+](=O)c1cc2NC(=O)C(=O)Nc2cc1[N+]([O-])=O

InChI

1S/C8H4N4O6/c13-7-8(14)10-4-2-6(12(17)18)5(11(15)16)1-3(4)9-7/h1-2H,(H,9,13)(H,10,14)

InChI key

RWVIMCIPOAXUDG-UHFFFAOYSA-N

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Gene Information

human ... GRIA1(2890), GRIA2(2891), GRIK1(2897), GRIK2(2898), GRIK3(2899), GRIK4(2900), GRIK5(2901)
mouse ... Gria1(14799)
rat ... Gria1(50592), Grik1(29559), Grik4(24406), Grin2a(24409)

Gene Information

human ... PDE3A(5139), PDE4A(5141), PDE4B(5142), PDE4C(5143), PDE4D(5144)

Gene Information

human ... ADORA1(134), ADORA2A(135), ADORA2B(136), ADORA3(140)
rat ... Adora1(29290), Adora2a(25369)

Gene Information

rat ... Gria1(50592), Grik1(29559), Grik2(54257), Grik4(24406), Grin2a(24409)

Application

DNQX has been used to block N-Methyl-D-aspartic acid (NMDA) and α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors in various experiments.

Biochem/physiol Actions

DNQX is a quinoxaline derivative.
A competitive kainate, quisqualate (non-NMDA) glutamate receptor antagonist.

Features and Benefits

This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound is featured on the Glutamate Receptors (Ion Channel Family) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

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