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D3943

Sigma-Aldrich

DAPH

≥98% (HPLC), solid

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Synonym(s):
4,5-Dianilinophthalimide, 5,6-Bis(phenylamino)-1H-isoindole-1,3(2H)-dione, CGP 52411
Empirical Formula (Hill Notation):
C20H15N3O2
CAS Number:
Molecular Weight:
329.35
MDL number:
PubChem Substance ID:
NACRES:
NA.77

Assay

≥98% (HPLC)

form

solid

color

orange

solubility

DMSO: >20 mg/mL
H2O: insoluble

storage temp.

2-8°C

SMILES string

O=C1NC(=O)c2cc(Nc3ccccc3)c(Nc4ccccc4)cc12

InChI

1S/C20H15N3O2/c24-19-15-11-17(21-13-7-3-1-4-8-13)18(12-16(15)20(25)23-19)22-14-9-5-2-6-10-14/h1-12,21-22H,(H,23,24,25)

InChI key

AAALVYBICLMAMA-UHFFFAOYSA-N

Gene Information

human ... EGFR(1956)

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1 of 4

This Item
H9415SML2418SML1013
DAPH ≥98% (HPLC), solid

Sigma-Aldrich

D3943

DAPH

5HPP-33 ≥98% (HPLC), solid

Sigma-Aldrich

H9415

5HPP-33

PS10 ≥98% (HPLC)

Sigma-Aldrich

SML2418

PS10

PRT4165 ≥98% (HPLC)

Sigma-Aldrich

SML1013

PRT4165

form

solid

form

solid

form

powder

form

powder

color

orange

color

white to off-white

color

white to beige

color

white to beige

solubility

DMSO: >20 mg/mL, H2O: insoluble

solubility

DMSO: >20 mg/mL

solubility

DMSO: 2 mg/mL, clear

solubility

DMSO: 20 mg/mL, clear

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

Quality Level

100

Quality Level

100

Quality Level

-

Quality Level

100

Biochem/physiol Actions

DAPH is an inhibitor of Aβ fibril formation; Protein tyrosine kinase inhibitor, specific for EGFR.

Features and Benefits

This compound is featured on the EGFR page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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M Slevin et al.
Journal of cellular and molecular medicine, 9(1), 85-102 (2005-03-24)
Current understanding of the patho-physiological events that follow acute ischaemic stroke suggests that treatment regimens could be improved by manipulation of gene transcription and protein activation, especially in the penumbra region adjacent to the infarct. An immediate reduction in excitotoxicity
Barbara J Blanchard et al.
Proceedings of the National Academy of Sciences of the United States of America, 101(40), 14326-14332 (2004-09-25)
The Abeta1-42 peptide that is overproduced in Alzheimer's disease (AD) from a large precursor protein has a normal amino acid sequence but, when liberated, misfolds at neutral pH to form "protofibrils" and fibrils that are rich in beta-sheets. We find
Wei Zhang et al.
International immunopharmacology, 72, 195-203 (2019-04-17)
The bacterial pneumonia caused by methicillin-resistant Staphylococcus aureus (MRSA) is a potentially fatal disease, featured with extensive infection, inflammation, and airway dysfunction. With the increasing emerging of drug-resistant strains, new therapeutic strategies beyond canonical antibiotic treatment are pressingly needed. Daphnetin
Marco Breinig et al.
Molecular systems biology, 11(12), 846-846 (2015-12-25)
Small molecules often affect multiple targets, elicit off-target effects, and induce genotype-specific responses. Chemical genetics, the mapping of the genotype dependence of a small molecule's effects across a broad spectrum of phenotypes can identify novel mechanisms of action. It can
Mohamed R Mohamed et al.
Environmental toxicology and pharmacology, 38(2), 531-541 (2014-08-30)
Among various phytochemicals, coumarins comprise a very large class of plant phenolic compounds that have good nutritive value, in addition to their antioxidant effects. The purpose of the present study was to investigate the protective effects of two coumarin derivatives

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