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H7630

Sigma-Aldrich

Hyaluronic acid sodium salt from bovine vitreous humor

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Synonym(s):
Poly(β-glucuronic acid-[1→3]-β-N-acetylglucosamine-[1→4]), alternating
Linear Formula:
(C14H21NaNO11)n
CAS Number:
MDL number:
NACRES:
NA.77

biological source

bovine (vitreous humor)

form

powder

color

white

solubility

water: ~5 g/L

storage temp.

−20°C

InChI

1S/C28H44N2O23.Na/c1-5(33)29-9-18(11(35)7(3-31)47-25(9)46)49-28-17(41)15(39)20(22(53-28)24(44)45)51-26-10(30-6(2)34)19(12(36)8(4-32)48-26)50-27-16(40)13(37)14(38)21(52-27)23(42)43;/h7-22,25-28,31-32,35-41,46H,3-4H2,1-2H3,(H,29,33)(H,30,34)(H,42,43)(H,44,45);/q;+1/t7-,8-,9-,10-,11-,12-,13+,14+,15-,16-,17-,18-,19-,20+,21+,22+,25-,26+,27-,28-;/m1./s1

InChI key

YWIVKILSMZOHHF-QJZPQSOGSA-N

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1 of 4

This Item
53747H9390H5388
Quality Level

200

Quality Level

200

Quality Level

200

Quality Level

200

color

white

color

white

color

white

color

white

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

solubility

water: ~5 g/L

solubility

H2O: 5 mg/mL, clear, colorless

solubility

water: 20 mg/mL, clear, colorless

solubility

water: ~5 g/L

biological source

bovine (vitreous humor)

biological source

(Streptococcus equi)

biological source

bacterial (Streptococcus zooepidemicus)

biological source

chicken (rooster comb)

Application

Hyaluronic acid sodium salt from bovine vitreous humor has been used:
  • as a component for the generation of artificial synovial fluid
  • to investigate its role in inducing oxidative stress and interleukin 8(IL-8) production in human nasal RPMI 2650 cells
  • to test its effect on B cell proliferation
  • as a substrate in neuraminidase assay of morbilliviruses virus

Biochem/physiol Actions

High molecular mass polymer composed of repeating dimeric units of glucuronic acid and N-acetyl glucosamine which forms the core of complex proteoglycan aggregates found in extracellular matrix.
Hyaluronic acid (HA) is abundantly present in the bovine vitreous humor. It corresponds to a molecular weight of 69293.9Da and has an isoelectric pH of 5.82. Bovine HA has high levels of endotoxins and it polydisperse with DNA and RNA contaminants. The enzyme HA synthases at the plasma membrane (HASs) aids in the synthesis of circulatory HA. HA is implicated in many physiological processes including inflammation, immune regulation, adhesion, embryo development and tumor progression.

Other Notes

To gain a comprehensive understanding of our extensive range of Polysaccharides for your research, we encourage you to visit our Carbohydrates Category page.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves


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Evaluation of hyaluronic acid in cattle: physiological variations related to age, periparturition and in clinical cases of paratuberculosis
Jolly A, et al.
Journal of Veterinary Science and Technology, 7(4), 342-346 (2016)
Evaluation of Hyaluronan from Different Sources: Streptococcus z ooepidemicus, Rooster Comb, Bovine Vitreous, and Human Umbilical Cord
Shiedlin A, et al.
Biomacromolecules, 5(6), 2122-2127 (2004)
Yi-Wen Lin et al.
Molecules (Basel, Switzerland), 25(19) (2020-10-01)
Osteoarthritis (OA) is the most common joint disease type and is accompanied by varying degrees of functional limitation. Both hyaluronic acid (HA) joint injections and pain relievers are efficient treatments for early-stage osteoarthritis. However, for the decomposition by hyaluronidase and
Sequence and structure alignment of Paramyxoviridae attachment proteins and discovery of enzymatic activity for a morbillivirus hemagglutinin.
Langedijk JP, et al.
Journal of virology, 71(8), 6155-6167 (1997)
Role of the biomolecular interactions in the structure and tribological properties of synovial fluid
Mirea DA, et al.
Tribology International, 59(4), 302-311 (2013)

Articles

There are five identified glycosaminoglycan chains (see Figure 1): Hyaluronan is not sulfated, but the other glycosaminoglycan chains contain sulfate substituents at various positions of the chain.

Glycosaminoglycans are large linear polysaccharides constructed of repeating disaccharide units.

Protocols

This procedure may be used for Hyaluronidase products.

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