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S8809

Sigma-Aldrich

Monoclonal Anti-Sodium Channel, Pan antibody produced in mouse

~1 mg/mL, clone K58/35, purified immunoglobulin

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MDL number:
NACRES:
NA.41

biological source

mouse

Quality Level

conjugate

unconjugated

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

K58/35, monoclonal

species reactivity

mammals

concentration

~1 mg/mL

technique(s)

immunohistochemistry (frozen sections): suitable
indirect immunofluorescence: 1 μg/mL using sciatic and optic nerve sections; cultured hypocampal neurons
western blot: 1 μg/mL using crude brain membrane prep (rat)

isotype

IgG1

UniProt accession no.

shipped in

wet ice

storage temp.

−20°C

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S0438S6936WH0006334M4
biological source

mouse

biological source

rabbit

biological source

rabbit

biological source

mouse

species reactivity

mammals

species reactivity

rat

species reactivity

rat

species reactivity

rat, mouse, human

antibody form

purified immunoglobulin

antibody form

affinity isolated antibody

antibody form

affinity isolated antibody

antibody form

purified immunoglobulin

conjugate

unconjugated

conjugate

unconjugated

conjugate

unconjugated

conjugate

unconjugated

clone

K58/35, monoclonal

clone

polyclonal

clone

polyclonal

clone

4G7, monoclonal

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General description

Voltage-gated sodium channels/VGSCs (Nav) are transmembrane proteins that are initiated by the depolarization of the membrane. They are heteromultimers with large pore-forming α-subunits and smaller β-subunits.

Specificity

The sequence recognized by this clone is identical in all known vertebrate Na+ channels. In cultured hippocampal neurons, the antibody specifically stains the axon initial segment. In sciatic and optic nerves, it stains the nodes of Ranvier.

Immunogen

synthetic peptide CTEEQKKYYNAMKKLGSKK from the intracellular III-IV loop of Na+ channels

Application

Monoclonal Anti-Sodium Channel, Pan antibody produced in mouse has been used in:
  • immunohistochemistry(1:50)
  • immunostaining (1:200)
  • immunofluorescence
  • immunocytochemistry (1:100)

Biochem/physiol Actions

Voltage-gated sodium channels/VGSCs (Nav) participates in nociceptive transmission. They play a key role in regulating the exchange between the extracellular and intracellular spaces. VGSCs are crucial for the initiation and firing of action potentials. They participate in neuronal excitability. Hence mutations in the VGSC genes results in several epileptic disorders.

Physical form

Solution in 10 mM Tris, pH 7.5, containing 0.1 m NaCl, 30% glycerol, and 15 mM sodium azide.

Legal Information

Sold under exclusive license from SUNY Stony Brook.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Amanda L York et al.
eNeuro, 4(4) (2017-08-12)
The neuromuscular junction (NMJ) is a chemical synapse formed between motoneurons and skeletal muscle fibers. The vertebrate NMJ uses acetylcholine (ACh) as the neurotransmitter and features numerous invaginations of the postsynaptic muscle membrane termed junctional folds. ACh receptors (AChRs) are
Analgesic and antipyretic natural products
Shilpi JA and Uddin SJ
Annual Reports in Medicinal Chemistry, 55, 435-458 (2020)
Larisa C Kruger et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 36(23), 6213-6224 (2016-06-10)
Voltage-gated sodium channel (VGSC) β subunits signal through multiple pathways on multiple time scales. In addition to modulating sodium and potassium currents, β subunits play nonconducting roles as cell adhesion molecules, which allow them to function in cell-cell communication, neuronal
Elisa D'Este et al.
Proceedings of the National Academy of Sciences of the United States of America, 114(2), E191-E199 (2016-12-23)
We used stimulated emission depletion (STED) superresolution microscopy to analyze the nanoscale organization of 12 glial and axonal proteins at the nodes of Ranvier of teased sciatic nerve fibers. Cytoskeletal proteins of the axon (betaIV spectrin, ankyrin G) exhibit a
Katarzyna Dover et al.
Nature communications, 7, 12895-12895 (2016-09-27)
Neurons in vertebrate central nervous systems initiate and conduct sodium action potentials in distinct subcellular compartments that differ architecturally and electrically. Here, we report several unanticipated passive and active properties of the cerebellar granule cell's unmyelinated axon. Whereas spike initiation

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