T8158
Transferrin human
powder, BioReagent, suitable for cell culture
Synonym(s):
Siderophilin, partially saturated
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About This Item
Recommended Products
product line
BioReagent
Quality Level
assay
≥98%
form
powder
concentration
~25 mM
technique(s)
cell culture | mammalian: suitable
impurities
endotoxin, tested
hepatitis and HIV antibody, none detected
solubility
H2O: 50 mg/mL
UniProt accession no.
shipped in
ambient
storage temp.
−20°C
Gene Information
human ... TF(7018)
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General description
Transferrin is a glycoprotein with a branched carbohydrate chain, having two sites for ferric ion binding in its polypeptide chain.
Application
Transferrin human has been used:
- to incubate human proximal tubule cells (HKC) - 8 cells along with IgG for the examination of albumin specificity
- as a supplement in serum-containing/devoid medium for human thyroid cell culture
- as a target glycoprotein to develop an in-gel hydrazinolysis method
Biochem/physiol Actions
Transferrin mediates iron transportation from plasma to cells. The iron-bound transferrin are of three forms: monoferric A/B transferrin and diferric transferrin. The transferrin binds to specific cell surface receptors and are internalized by endocytosis. Once inside, the iron is released into the cells and the iron-free transferrin, also referred to as apotransferrin, is exocytosed outside the cell without being degraded. Transferrin is known to deliver iron to cells in a physiologically safe and effective form.
Other Notes
Partially iron-saturated
Preparation Note
Heat treated at 60 °C for ten hours.
Analysis Note
Purity by agarose electrophoresis.
Disclaimer
RESEARCH USE ONLY. This product is regulated in France when intended to be used for scientific purposes, including for import and export activities (Article L 1211-1 paragraph 2 of the Public Health Code). The purchaser (i.e. enduser) is required to obtain an import authorization from the France Ministry of Research referred in the Article L1245-5-1 II. of Public Health Code. By ordering this product, you are confirming that you have obtained the proper import authorization.
related product
Product No.
Description
Pricing
Storage Class
11 - Combustible Solids
wgk_germany
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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Understand how transferrin affects serum-free cell culture systems, crucial for biomanufacturing heterologous proteins like monoclonal antibodies.
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