T8904

Thiabendazole

≥99%, powder

• Synonym(s): 2-(4-Thiazolyl)benzimidazole
• Empirical Formula (Hill Notation): C₁₀H₇N₃S
• CAS Number: 148-79-8
• Molecular Weight: 201.25
• Beilstein/REAXYS Number: 611403
• EC Number: 205-725-8
• MDL number: MFCD00005587
• UNSPSC Code: 51453501
• PubChem Substance ID: 24900571
• NACRES: NA.85

Properties

• Quality Level: 200
• assay: ≥99%
• form: powder
• color: white to off-white
• solubility: DMF: soluble 50 mg/mL
• antibiotic activity spectrum: fungi; parasites
• mode of action: enzyme | inhibits
• SMILES string: c1ccc2[nH]c(nc2c1)-c3cscn3
• InChI: 1S/C10H7N3S/c1-2-4-8-7(3-1)12-10(13-8)9-5-14-6-11-9/h1-6H,(H,12,13)
• Inchi Key: WJCNZQLZVWNLKY-UHFFFAOYSA-N
• Gene Information: human ... CYP2C9(1559)

Description

General description

Chemical structure: imidazole

Application

Thiabendazole (TBZ) is a broad-spectrum antihelminthic and is used to treat parasitic infections in humans. It is used as an agricultural fungicide and as a food preservative. Thiabendazole has been used as a heavy metal chelating detoxification agent. It is used clinically to treat threadworm, cutaneous larva migrans, visceral larva migrans, and trichinosis.

Biochem/physiol Actions

Thiabendazole inhibits anaerobic respiration at the level of mitochondrial helminth-specific enzyme. It acts as a quinol-fumarate reductase (QFR) inhibitor in ,C. jejuni and H. pylori, blocking quinol oxidation to quinone. Thiabendazole suppresses egg and larval production and may inhibit the subsequent development of eggs and larvae which are passed in feces. A proposed route of biotransformation of thiabendazole is the CYP1A2-catalyzed hydroxylation to 5-hydroxythiabendazole, which is metabolized to glucuronide and sulfate conjugates.

Other Notes

Keep container tightly closed in a dry and well-ventilated place.Keep in a dry place.Storage class (TRGS 510): Non Combustible Solids

Safety Information

• pictograms: GHS09
• signalword: Warning
• hcodes: H410
• pcodes: P273 - P391 - P501
• Hazard Classifications: Aquatic Acute 1 - Aquatic Chronic 1
• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 2
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves