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ATP1A1

ATPase, Na+/K+ transporting, alpha 1 polypeptide

Synonyms:
Species:
UniProtKB ID:
Gene ID:
  • Human(476) Summary: The protein encoded by this gene belongs to the family of P-type cation transport ATPases, and to the subfamily of Na+/K+ -ATPases. Na+/K+ -ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These gradients are essential for osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical excitability of nerve and muscle. This enzyme is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta). The catalytic subunit of Na+/K+ -ATPase is encoded by multiple genes. This gene encodes an alpha 1 subunit. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2009]
  • Mouse(11928) ATPase, Na+/K+ transporting, alpha 1 polypeptide
  • Rat(24211) ATPase, Na+/K+ transporting, alpha 1 polypeptide
  • domestic cat(101083695) ATPase, Na+/K+ transporting, alpha 1 polypeptide
  • Horse(100034139) ATPase, Na+/K+ transporting, alpha 1 polypeptide
  • dog(403992) ATPase, Na+/K+ transporting, alpha 1 polypeptide
  • chicken(396530) ATPase, Na+/K+ transporting, alpha 1 polypeptide
  • Domestic Rabbit(100302415) ATPase, Na+/K+ transporting, alpha 1 polypeptide
  • sheep(443381) ATPase, Na+/K+ transporting, alpha 1 polypeptide
  • cow(282144) ATPase, Na+/K+ transporting, alpha 1 polypeptide
  • naked mole-rat(101697634) ATPase, Na+/K+ transporting, alpha 1 polypeptide
  • domestic guinea pig(100192382) ATPase, Na+/K+ transporting, alpha 1 polypeptide

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Small Molecule - Activator

Product Number
Description
Species
Digitoxigenin, ,
Species
rat

Antibodies

Product Number
Description
Species Reactivity
Application
Monoclonal Anti-Na+/K+ ATPase (α Subunit) antibody produced in mouse, clone M7-PB-E9, ascites fluid,
Species Reactivity
bovine, canine, chicken, human, mouse, pig, sheep
Application
ELISA
immunocytochemistry

immunofluorescence

immunohistochemistry

immunoprecipitation (IP)

western blot
Anti-phospho-ATP1 α1/Na+K+ ATPase1 (pSer23) antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human, mouse, rat
Application
ELISA
immunofluorescence

western blot
Anti-ATP1 α antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
rat
Application
ELISA
immunofluorescence

western blot
Anti-ATPASE antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human, mouse, rat
Application
ELISA
immunofluorescence

immunohistochemistry

western blot
Anti-Na+/K+-ATPase antibody produced in rabbit, ,
Species Reactivity
human, mouse, rat
Application
immunohistochemistry
western blot

Small Molecule - Inhibitor

Product Number
Description
Species
Melittin, ≥97% (HPLC), synthetic,
Species
mouse, rat, human
Digoxin, analytical standard,
Species
human
Digoxin, United States Pharmacopeia (USP) Reference Standard,
Species
human
Digitoxin for LC assay, European Pharmacopoeia (EP) Reference Standard,
Species
human
Digoxin, European Pharmacopoeia (EP) Reference Standard,
Species
human

Proteins

Product Number
Description
Species
Adenosine 5′-Triphosphatase from porcine cerebral cortex, lyophilized powder, ≥0.3 units/mg protein, pH 7.8,
Species

esiRNA

Product Number
Description
Species
MISSION® esiRNA, targeting mouse Atp1a1,
Species
mouse
MISSION® esiRNA, targeting human ATP1A1,
Species
human